Anti-Neuronal Antibodies Type 1 (Anti-Hu); Anti-Neuronal Antibodies Type 2 (Anti-Ri); PCA Type 1 (Anti-Yo); Anti-Tr (DNER); Anti-GAD65; Anti-Zic 4; Anti-TITIN; Anti-SOX1; Anti-Recoverin; Anti-PMA2 (Ma2/Ta); Anti-CV2; Anti-Amphiphysin; APNA Comment
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Paraneoplastic Autoantibodies Panel (LRC), Serum
Test ID: APNA
Test
Method
Immunoblotting
Platform
Euroimmun EuroBlot Master 44
Report Includes
Specimens
Serum
Important Note: TEST ID APNA
Non-interfaced clients should specify the Test ID APNA when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: Similar tests are offered by other ICL supplier labs:
Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum
Important Note: TEST ID APNA
Non-interfaced clients should specify the Test ID APNA when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: Similar tests are offered by other ICL supplier labs:
Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum
Clinical Utility
Anti-neuronal antibodies are used as an aid in the diagnosis of neurologic syndromes. These antibodies are detected in the serum and CSF of a majority of patients with typical paraneoplastic syndromes and are not present in normal individuals.
Test Version
6-Mar-2023
Specimen
Specimens
Serum
Important Note: TEST ID APNA
Non-interfaced clients should specify the Test ID APNA when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: Similar tests are offered by other ICL supplier labs:
Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum
Important Note: TEST ID APNA
Non-interfaced clients should specify the Test ID APNA when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: Similar tests are offered by other ICL supplier labs:
Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum
Sample Volume
1 mL
Collection & Handling
Handling Information
Store and send cold or frozen.
Stability
| Refrigerated | 7 days |
|---|---|
| Frozen | >7 days |
Rejection Criteria
| Hemolysis | Gross |
|---|---|
| Lipemia | Gross |
| Specimen | Gross microbial contamination |
Test Version
6-Mar-2023
Performance / Interpretation
Method
Immunoblotting
Platform
Euroimmun EuroBlot Master 44
Turnaround Time
15 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Anti-Neuronal Antibodies Type 1 (Anti-Hu) |
|
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| Anti-Neuronal Antibodies Type 2 (Anti-Ri) |
|
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| PCA Type 1 (Anti-Yo) |
|
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| Anti-Tr (DNER) |
|
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| Anti-GAD65 |
|
|||
| Anti-Zic 4 |
|
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| Anti-TITIN |
|
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| Anti-SOX1 |
|
|||
| Anti-Recoverin |
|
|||
| Anti-PMA2 (Ma2/Ta) |
|
|||
| Anti-CV2 |
|
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| Anti-Amphiphysin |
|
|||
| APNA Comment |
|
|||
|
Results in the borderline range will be reported with the comment "Results in the borderline range should be evaluated as increased but negative".
|
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Test Version
6-Mar-2023
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| APNA | 28626ANNA1 (ANTI-HU) | |
| 28627ANNA2 (ANTI-RI) | ||
| 28625PCA1 (ANTI-YO) | ||
| 64320ANTI-TR (DNER) | ||
| 64321ANTI-GAD65 | ||
| 64322ANTI-ZIC 4 | ||
| 64323ANTI-TITIN | ||
| 64324ANTI-SOX1 | ||
| 64325ANTI-RECOVERIN | ||
| 64326ANTI-PMA2 (MA2/TA) | ||
| 64327ANTI-CV2 | ||
| 64328ANTI-AMPHIPHYSIN | ||
| 64331APNA COMMENT |
Test Version
6-Mar-2023