Back to Test Catalogue

Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma

Test ID: PNPA SP

Test

Method

Various

Method Description

Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.

Platform

Immunoblot: EUROBlotOne

Report Includes

Anti-Amphiphysin; Anti-CV2; Anti-GAD65; Anti-Hu; Anti-Ma2:Ta; Anti-Recoverin; Anti-Ri; Anti-SOX1; Anti-Titin; Anti-Tr (DNER); Anti-Yo; Anti-Zic4

Specimens

Serum; Plasma

Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum

Clinical Utility

A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

6-Mar-2023

Specimen

Specimens

Serum; Plasma

Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum

Collection Containers

Preferred

Gold top (clot activator & gel); Red top (no additive)

Acceptable

Lavender top (EDTA); Green top (lithium or sodium heparin); Blue top (3.2% buffered citrate)

Sample Volume

2.0 mL

Minimum Volume

0.5 mL

Pediatric Volume

0.5 mL

Collection & Handling

Handling Information

Store and send cold or frozen.

Stability

Ambient Unacceptable
Refrigerated 14 days
Frozen >14 days

Test Version

6-Mar-2023

Performance / Interpretation

Method

Various

Method Description

Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.

Platform

Immunoblot: EUROBlotOne

Turnaround Time

17 days

Results

Name Units Reference Range Conversion Factor
Anti-Amphiphysin Immunoblot
  • Negative
Anti-CV2 Immunoblot
  • Negative
Anti-GAD65 Immunoblot
  • Negative
Anti-Hu Immunoblot
  • Negative
Anti-Ma2:Ta Immunoblot
  • Negative
Anti-Recoverin Immunoblot
  • Negative
Anti-Ri Immunoblot
  • Negative
Anti-SOX1 Immunoblot
  • Negative
Anti-Titin Immunoblot
  • Negative
Anti-Tr (DNER) Immunoblot
  • Negative
Anti-Yo Immunoblot
  • Negative
Anti-Zic4 Immunoblot
  • Negative

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

6-Mar-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
Multiple 0HL7 codes

Test Version

6-Mar-2023