Parathyroid Hormone Related Peptide N-Terminal (PTHrP), Plasma
Test Overview
Clinical Utility
Aiding in the evaluation of patients with hypercalcemia of unknown origin. Aiding in the evaluation of patients with suspected humoral hypercalcemia of malignancy. The test should not be used to exclude cancer or screen tumor patients for humoral hypercalcemia of malignancy. Two PTHrP assays are offered, one targeting the N-terminal peptides (Parathyroid Hormone Related Peptide N-Terminal (PTHrP), Plasma) and the other targeting the C-terminal peptides (Parathyroid Hormone Related Protein C-Terminal (PTHrP), Plasma). The C-terminal fragment may accumulate in patients with renal impairment and the N-terminal fragment clearance is not affected by renal impairment. To avoid detection of excess C-terminal fragments in renal impairment choose the N-terminal assay. Reference link
Method
Immunochemiluminometric Assay (ICMA)
Method Description
The parathyroid hormone-related peptide (PTHrP) assay is a plate-based chemiluminescent assay utilizing an anti-PTHrP rabbit-polyclonal antibody for capture and an acridinium ester anti-PTHrP goat-polyclonal antibody for detection. The assay targets 1-86 PTHrP.(Unpublished Mayo method)
Result Included
PTH-Related Peptide; Parathyroid Related Polypeptide; Parathyroid Related Protein; PTH Related Protein
Specimen
Specimen Type
Plasma (EDTA)You must specify "Mayo" or "N-Terminal" to order this test.
Please note that PTHrP analysis as a C-Terminal assay is available at Quest: Parathyroid Hormone Related Protein C-Terminal (PTHrP), Plasma.
Containers
Collection Containers
Lavender top (EDTA)
Volume
Sample Volume
0.7 mL
Minimum Volume
0.25 mL
Collection & Handling
Collection Instructions
Use ice-cooled collection tube.
Handling Information
Separate plasma in a refrigerated centrifuge or in chilled centrifuge cups. Store and send frozen.
Additional Information
You must specify “Mayo” or “N-Terminal” to order this test.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| Unacceptable | Unacceptable | 30 days |
Performance & Interpretation
Turnaround Time
10 days
Results
-
PTH-Related Peptidepmol/L≤4.2
Referral Location
Out-of-Country
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| PRPMAY | PTH-Related Peptide | 38824 | pmol/L |
Test Version
Last Updated
2024-12-09