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Neuromyelitis Optica Spectrum Profile, CSF; test site LHSC

Test ID: NMOSP CSF

Test

Aliases/Synonyms

Anti Myelin Oligodendrocyte; Glycoprotein and Anti Aquaporin4 IgG; Anti AQP4 antibody; Anti NMO antibody; Anti MOG antibody; NMOSDCSF

Method

Recombinant Cell-based Immunofluorescence Assay (IFA)

Report Includes

Anti-AQP4; Anti-MOG

Specimens

CSF

Important Note:
Neuromyelitis Optica testing is available at multiple testing labs. Non-interfaced clients should specify the Test ID NMOSP CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.

Clinical Utility

This test can be used to help distinguish between Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD).

A single autoantibody test is not diagnostic and should not be used to determine course of treatment. The test result must be evaluated with consideration of clinical presentation, patient history and other laboratory tests.

Testing for AQP4 and MOG antibodies may be more sensitive in serum than in CSF. CSF testing should only be considered in patients receiving acute immunotherapy such as plasma exchange, and should be accompanied by a serum sample.

Serum testing is performed at an additional fee, and can be ordered using Test ID NMOSP S. See the web listing for Neuromyelitis Spectrum Profile, Serum. 

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

22-Mar-2024

Specimen

Specimens

CSF

Important Note:
Neuromyelitis Optica testing is available at multiple testing labs. Non-interfaced clients should specify the Test ID NMOSP CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.

Collection Containers

Sterile Container

Sample Volume

2 mL

Minimum Volume

1 mL

Collection & Handling

Handling Information

Store and send frozen. Avoid freeze/thaw cycles.

Additional Information

MOG titer is performed when MOG is positive at no additional fee.

Stability

Refrigerated 14 days
Frozen >14 days

Additional Stability Information

Avoid freeze/thaw cycles.

Test Version

22-Mar-2024

Performance / Interpretation

Method

Recombinant Cell-based Immunofluorescence Assay (IFA)

Turnaround Time

9 days

Results

Name Units Reference Range Conversion Factor
Anti-AQP4,CSF
  • Negative
Anti-MOG,CSF
  • Negative

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

22-Mar-2024

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
NMOSP CSF 63527Anti-AQP4,CSF
63528Anti-MOG,CSF

Test Version

22-Mar-2024