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Neuromyelitis Optica Spectrum Profile, Serum; test site LHSC

Test ID: NMOSP S

Test

Aliases/Synonyms

Anti Myelin Oligodendrocyte Glycoprotein and Anti Aquaporin4 IgG; Anti AQP4 antibody; Anti NMO antibody; Anti MOG antibody; NMOSD

Method

Recombinant Cell-based Immunofluorescence Assay (IFA)

Report Includes

Anti-AQP4; Anti-MOG

Specimens

Serum; Plasma

Important Note: Neuromyelitis Optica testing is available at multiple testing labs. Non-interfaced clients should specify the Test ID NMOSP S when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.

Clinical Utility

This test can be used to help distinguish between Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD).

A single autoantibody test is not diagnostic and should not be used to determine course of treatment. The test result must be evaluated with consideration of clinical presentation, patient history and other laboratory tests.

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

22-Mar-2024

Specimen

Specimens

Serum; Plasma

Important Note: Neuromyelitis Optica testing is available at multiple testing labs. Non-interfaced clients should specify the Test ID NMOSP S when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.

Collection Containers

Preferred

Gold top (clot activator & gel); Red top (no additive)

Acceptable

Lavender top (EDTA); Green top (lithium or sodium heparin); Blue top (3.2% buffered citrate)

Sample Volume

2 mL

Minimum Volume

1 mL

Collection & Handling

Handling Information

Store and send frozen. Avoid freeze/thaw cycles.

Additional Information

MOG titer is performed when MOG is positive at no additional fee.

Stability

Refrigerated 14 days
Frozen >14 days

Additional Stability Information

Avoid freeze/thaw cycles.

Test Version

22-Mar-2024

Performance / Interpretation

Method

Recombinant Cell-based Immunofluorescence Assay (IFA)

Turnaround Time

9 days

Results

Name Units Reference Range Conversion Factor
Anti-AQP4,S
  • Negative
Anti-MOG,S
  • Negative

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

22-Mar-2024

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
NMOSP S 63525Anti-AQP4,S
63526Anti-MOG,S

Test Version

22-Mar-2024