Paraneoplastic antibodies
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Comprehensive Autoimmune Encephalitis Panel (LHSC) , CSF
Test ID: AEP CSF
Test
Aliases/Synonyms
Method
Various
Method Description
Cell-based assay (CBA) and tissue indirect immunofluorescence (TIIF) assay for autoimmune encephalitis antibodies (reported based on CBA).
Immunoblot and tissue indirect immunofluorescence (TIIF) assay for paraneoplastic antibodies (reported based on immunoblot).
ELISA and immunoblot for Anti-GAD65.
Each sample will also be screened for neural antibodies based on research use-only TIIF, only negative reported on a research basis.
Report Includes
Autoimmune Encephalitis Antibodies:; Anti-NMDAR; Anti-LGI1; Anti-CASPR2; Anti-AMPAR1/R2; Anti-GABARB1/B2; Anti-DPPX
Paraneoplastic Antibodies:Anti-Hu (ANNA-1); Anti-Ri (ANNA-2); Anti-Yo (PCA-1); Anti-Amphiphysin; Anti-CV2 (CRMP5); Anti-Ma2/Ta (PNMA2); Anti-Tr (DNER); Anti-Zic4; Anti-Recoverin; Anti-Titin; Anti-SOX1;
Other Antibody: Anti-GAD65
Research-only Neural Antibodies:; Anti-GFAP; Anti-mGluR1; Anti-NIF; Anti-Neurochondrin; ANNA-3; PCA-2/Anti-MAP1B; Anti-AP3B2; Anti-PDE10A; Anti-KLHL11; Anti-ITPR1; Anti-GRAF
Paraneoplastic Antibodies:Anti-Hu (ANNA-1); Anti-Ri (ANNA-2); Anti-Yo (PCA-1); Anti-Amphiphysin; Anti-CV2 (CRMP5); Anti-Ma2/Ta (PNMA2); Anti-Tr (DNER); Anti-Zic4; Anti-Recoverin; Anti-Titin; Anti-SOX1;
Other Antibody: Anti-GAD65
Research-only Neural Antibodies:; Anti-GFAP; Anti-mGluR1; Anti-NIF; Anti-Neurochondrin; ANNA-3; PCA-2/Anti-MAP1B; Anti-AP3B2; Anti-PDE10A; Anti-KLHL11; Anti-ITPR1; Anti-GRAF
Specimens
CSF
Submission of a concurrent serum is recommended (separate billing): Comprehensive Autoimmune Encephalitis Panel (LHSC) , Serum
Submission of a completed Autoimmune Encephalitis Panel Questionnaire is recommended to facilitate laboratory interpretation and prompt clinical-serological correlation by a laboratory scientist with the ordering physician.
Paraneoplastic Antibodies included in this Panel may be ordered on their own: Paraneoplastic Antibodies Expanded Panel (LHSC), CSF
Submission of a concurrent serum is recommended (separate billing): Comprehensive Autoimmune Encephalitis Panel (LHSC) , Serum
Submission of a completed Autoimmune Encephalitis Panel Questionnaire is recommended to facilitate laboratory interpretation and prompt clinical-serological correlation by a laboratory scientist with the ordering physician.
Paraneoplastic Antibodies included in this Panel may be ordered on their own: Paraneoplastic Antibodies Expanded Panel (LHSC), CSF
Clinical Utility
A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.
Test Location
London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5
Test Version
25-Jul-2024
Specimen
Specimens
CSF
Submission of a concurrent serum is recommended (separate billing): Comprehensive Autoimmune Encephalitis Panel (LHSC) , Serum
Submission of a completed Autoimmune Encephalitis Panel Questionnaire is recommended to facilitate laboratory interpretation and prompt clinical-serological correlation by a laboratory scientist with the ordering physician.
Paraneoplastic Antibodies included in this Panel may be ordered on their own: Paraneoplastic Antibodies Expanded Panel (LHSC), CSF
Submission of a concurrent serum is recommended (separate billing): Comprehensive Autoimmune Encephalitis Panel (LHSC) , Serum
Submission of a completed Autoimmune Encephalitis Panel Questionnaire is recommended to facilitate laboratory interpretation and prompt clinical-serological correlation by a laboratory scientist with the ordering physician.
Paraneoplastic Antibodies included in this Panel may be ordered on their own: Paraneoplastic Antibodies Expanded Panel (LHSC), CSF
Sample Volume
1 mL
Collection & Handling
Handling Information
Store and send cold or frozen.
Stability
| Refrigerated | 14 days |
|---|---|
| Frozen | 30 days |
Test Version
25-Jul-2024
Performance / Interpretation
Method
Various
Method Description
Cell-based assay (CBA) and tissue indirect immunofluorescence (TIIF) assay for autoimmune encephalitis antibodies (reported based on CBA).
Immunoblot and tissue indirect immunofluorescence (TIIF) assay for paraneoplastic antibodies (reported based on immunoblot).
ELISA and immunoblot for Anti-GAD65.
Each sample will also be screened for neural antibodies based on research use-only TIIF, only negative reported on a research basis.
Turnaround Time
10 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Various |
|
|||
| Anti-GAD65 ELISA | IU/mL |
|
||
Test Location
London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5
Test Version
25-Jul-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| AEP CSF | 63469Anti-AMPAR1/R2 CBA,CSF | |
| 63470Anti-CASPR2 CBA,CSF | ||
| 63471Anti-DPPX CBA,CSF | ||
| 63472Anti-GABARB1/B2 CBA,CSF | ||
| 63473Anti-LGI1 CBA,CSF | ||
| 63474Anti-NMDAR CBA,CSF | ||
| 63475Anti-Amphiphysin Immunoblot, CSF | ||
| 63476Anti-CV2 Immunoblot, CSF | ||
| 63477Anti-GAD65 Immunoblot, CSF | ||
| 63478Anti-Hu Immunoblot, CSF | ||
| 63479Anti-Ma2:Ta Immunoblot, CSF | ||
| 63480Anti-SOX1 Immunoblot, CSF | ||
| 63481Anti-Recoverin Immunoblot, CSF | ||
| 63482Anti-Ri Immunoblot, CSF | ||
| 63483Anti-Titin Immunoblot, CSF | ||
| 63484Anti-Tr (DNER) Immunoblot, CSF | ||
| 63485Anti-Yo Immunoblot, CSF | ||
| 63486Anti-Zic4 Immunoblot, CSF | ||
| 63488Antibody Result, CSF | ||
| 63489Research Based Antibody Screen,TIIF,CSF |
Test Version
25-Jul-2024