Anti-Amphiphysin; Anti-CV2; Anti-GAD65; Anti-Hu; Anti-Ma2:Ta; Anti-Recoverin; Anti-Ri; Anti-SOX1; Anti-Titin; Anti-Tr (DNER); Anti-Yo; Anti-Zic4
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Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Test ID: PNPA SP
Test
Method
Various
Method Description
Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.
Platform
Immunoblot: EUROBlotOne
Report Includes
Specimens
Serum; Plasma
Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum
Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum
Clinical Utility
A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.
Test Version
25-Jul-2024
Specimen
Specimens
Serum; Plasma
Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum
Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum
Collection Containers
Preferred
Gold top (clot activator & gel); Red top (no additive)
Acceptable
Lavender top (EDTA); Green top (lithium or sodium heparin); Blue top (3.2% buffered citrate)
Sample Volume
2.0 mL
Minimum Volume
0.5 mL
Pediatric Volume
0.5 mL
Collection & Handling
Handling Information
Store and send cold or frozen.
Stability
| Ambient | Unacceptable |
|---|---|
| Refrigerated | 14 days |
| Frozen | 30 days |
Test Version
25-Jul-2024
Performance / Interpretation
Method
Various
Method Description
Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.
Platform
Immunoblot: EUROBlotOne
Turnaround Time
17 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Anti-Amphiphysin Immunoblot |
|
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| Anti-CV2 Immunoblot |
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| Anti-GAD65 Immunoblot |
|
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| Anti-Hu Immunoblot |
|
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| Anti-Ma2:Ta Immunoblot |
|
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| Anti-Recoverin Immunoblot |
|
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| Anti-Ri Immunoblot |
|
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| Anti-SOX1 Immunoblot |
|
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| Anti-Titin Immunoblot |
|
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| Anti-Tr (DNER) Immunoblot |
|
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| Anti-Yo Immunoblot |
|
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| Anti-Zic4 Immunoblot |
|
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Test Version
25-Jul-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| Multiple | 0HL7 codes |
Test Version
25-Jul-2024