Anti-Amphiphysin; Anti-CV2; Anti-GAD65; Anti-Hu; Anti-Ma2:Ta; Anti-Recoverin; Anti-Ri; Anti-SOX1; Anti-Titin; Anti-Tr (DNER); Anti-Yo; Anti-Zic4
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Paraneoplastic Antibodies Expanded Panel (LHSC), CSF
Test ID: PNPA CSF
Test
Method
Various
Method Description
Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.
Platform
Immunoblot: EUROBlotOne
Report Includes
Specimens
CSF
Submission of a concurrent serum is recommended (billed separately): Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Important Note: TEST ID PNPA CSF
Non-interfaced clients should specify the Test ID PNPA CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), CSF .
Submission of a concurrent serum is recommended (billed separately): Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Important Note: TEST ID PNPA CSF
Non-interfaced clients should specify the Test ID PNPA CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), CSF .
Clinical Utility
A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.
Test Location
London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5
Test Version
25-Jul-2024
Specimen
Specimens
CSF
Submission of a concurrent serum is recommended (billed separately): Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Important Note: TEST ID PNPA CSF
Non-interfaced clients should specify the Test ID PNPA CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), CSF .
Submission of a concurrent serum is recommended (billed separately): Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Important Note: TEST ID PNPA CSF
Non-interfaced clients should specify the Test ID PNPA CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), CSF .
Sample Volume
2.0 mL
Minimum Volume
0.5 mL
Pediatric Volume
0.5 mL
Collection & Handling
Handling Information
Store and send cold or frozen.
Stability
| Ambient | Unacceptable |
|---|---|
| Refrigerated | 14 days |
| Frozen | 30 days |
Test Version
25-Jul-2024
Performance / Interpretation
Method
Various
Method Description
Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.
Platform
Immunoblot: EUROBlotOne
Turnaround Time
17 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Anti-Amphiphysin Immunoblot |
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| Anti-CV2 Immunoblot |
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| Anti-GAD65 Immunoblot |
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| Anti-Hu Immunoblot |
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| Anti-Ma2:Ta Immunoblot |
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| Anti-Recoverin Immunoblot |
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| Anti-Ri Immunoblot |
|
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| Anti-SOX1 Immunoblot |
|
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| Anti-Titin Immunoblot |
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| Anti-Tr (DNER) Immunoblot |
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| Anti-Yo Immunoblot |
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| Anti-Zic4 Immunoblot |
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Test Location
London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5
Test Version
25-Jul-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| Multiple | 0HL7 codes |
Test Version
25-Jul-2024