Estradiol and Estrone by LC-MS/MS, Serum/Plasma

E1; E2; Estrogens

Estrone; Estradiol

Serum; Plasma

Simultaneous high-sensitivity determination of serum estrone and estradiol levels. Situations requiring either higher sensitivity estradiol measurement, estrone measurement, or both, including

• As part of the diagnosis and workup of precocious and delayed puberty
• As part of the diagnosis and workup of suspected disorders of sex steroid metabolism, (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)
• As an adjunct to clinical assessment, imaging studies, and bone mineral density measurement in the fracture risk assessment of postmenopausal women
• Monitoring low-dose female hormone replacement therapy in postmenopausal women
• Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)

In conjunction with luteinizing hormone measurements, monitoring of estrogen replacement therapy in hypogonadal premenopausal women.
Evaluation of feminization, including gynecomastia, in males.
Diagnosis of estrogen-producing neoplasms.