Clozaril
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Clozapine and Norclozapine, Plasma
Test ID: CLOZA
Test
Aliases/Synonyms
Method
LC-MSD
Report Includes
Clozapine; Norclozapine
Specimens
Avoid gel separator tubes; Plasma (EDTA); Plasma (Li Heparin); Serum
Clinical Utility
Toxic effects are centrally mediated (CNS) and concentration dependent.
Hematological effects, agranulocytosis, are concentration independent.
Test Version
15-Jan-2024
Specimen
Specimens
Avoid gel separator tubes; Plasma (EDTA); Plasma (Li Heparin); Serum
Collection Containers
Preferred
Plasma (EDTA lavender top)
Acceptable
Plasma (green top Li Heparin); Serum (red top)
Sample Volume
1 mL
Minimum Volume
0.5 mL
Specimen Comment
Avoid gel separator tubes.
Collection & Handling
Handling Information
Store and send frozen.
Test Version
15-Jan-2024
Performance / Interpretation
Method
LC-MSD
Turnaround Time
7 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Clozapine | nmol/L |
|
µg/L x 3.06 | |
| Norclozapine | nmol/L |
|
µg/L x 3.19 | |
Test Version
15-Jan-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| CLOZA | 20707Clozapine,S | nmol/L |
| 20708Norclozapine,S | nmol/L |
Test Version
15-Jan-2024