Pyrazinamide Level
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Pyrazinamide Level, Serum/Plasma
Test ID: PYRAZINL SP
Test
Method
LC-MS/MS
Report Includes
Specimens
Serum
Clinical Utility
Therapeutic Drug Monitoring (TDM) of pyrazinamide is used to optimize dosing, ensuring efficacy while minimizing toxicity. Pyrazinamide is a first-line anti-tuberculosis (TB) drug, primarily effective against Mycobacterium tuberculosis.
Test Version
19-Nov-2025
Specimen
Specimens
Serum
Collection Containers
Red top (no additive)
Sample Volume
2.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Allow to clot for 30 minutes, separate serum from cells immediately by centrifugation and aliquot into a labeled polypropylene or similar plastic tube. Store and send frozen.
Stability
| Ambient | 24 hours |
|---|---|
| Frozen | > 24 hours |
Additional Stability Information
Freeze at -70C if possible, but at minimum -20C.
Rejection Criteria
| Specimen | Thawed samples for greater than 24 hours |
|---|
Test Version
19-Nov-2025
Performance / Interpretation
Method
LC-MS/MS
Turnaround Time
14 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
|
||||
Test Version
19-Nov-2025
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| PYRAZINL SP | 65035Pyrazinamide Level | mcg/mL |
Test Version
19-Nov-2025