Itraconazole; Hydroxyitraconazole
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Itraconazole LC-MS/MS, Serum/Plasma
Test ID: ITRAEOR SP
Test
Method
LC-MS/MS
Report Includes
Specimens
Avoid gel separator tubes; Serum; Plasma
Test Location
The Ottawa Hospital General Campus, 501 Smyth Road, Ottawa ON K1H 8L6
Test Version
15-Nov-2024
Specimen
Specimens
Avoid gel separator tubes; Serum; Plasma
Collection Containers
Preferred
Green top (sodium heparin)
Acceptable
Red top (no additive)
Sample Volume
1.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Collection Instructions
Collect immediately before next scheduled dose or at least 12 hours after last dose.
Handling Information
Store and send frozen.
Stability
| Refrigerated | 1 day |
|---|---|
| Frozen | > 1 day |
Rejection Criteria
| Specimen | Collected in gel-separator tube |
|---|
Test Version
15-Nov-2024
Performance / Interpretation
Method
LC-MS/MS
Turnaround Time
10 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Itraconazole | µg/mL |
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| Hydroxyitraconazole | µg/mL |
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No therapeutic range has been established for hydroxyitraconazole; activity and serum concentrations are similar to parent drug. Some studies suggest hydroxyitraconazole levels are slightly higher than itraconazole levels, with a HO-itraconazole:itraconazole ratio 1.1 - 2.5. Other studies suggest the combined itraconazole and HO-itraconazole concentration should be >1.5 ug/mL.
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Test Location
The Ottawa Hospital General Campus, 501 Smyth Road, Ottawa ON K1H 8L6
Test Version
15-Nov-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| ITRAEOR SP | 65007Itraconazole | ug/mL |
| 65751Hydroxyitraconazole | ug/mL |
Test Version
15-Nov-2024