VMA; VMA/Creat Ratio; Creatinine
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Vanillylmandellic Acid (VMA) LC-MS/MS, 24hr Urine
Test ID: VMA
Orderable by Ontario ND
Test
Method
LC-MS/MS
Report Includes
Specimens
Urine (24 hr)
Test Location
St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8
Test Version
16-Nov-2022
Specimen
Specimens
Urine (24 hr)
Collection Containers
Urine Container (24hr) 4L
Sample Volume
10 mL
Patient Preparation
The following foods and medications should be avoided for three (3) days prior to the collection of urine, and during the collection of the sample:
Foods containing high caffeine concentrations (e.g. coffee, tea, cocoa, chocolate, caffeinated beverages, foods containing high amine concentrations (e.g. bananas, avocados, cheese, walnuts, alcohol, fruit and juices) and foods containing vanilla can increase urinary HVA/VMA excretion. Essential hypertension, intense anxiety and intense physical exercise can also result in raised HVA/VMA excretion.
Medications and drugs such as Salicylate, Histamine, Acetaminophen, Levodopa, Ajmaline, Lithium, Epinephrine, Nitroglycerin, Glucagon, Rauwolfia Alkaloids and Guanethidine can increase HVA/VMA.
Contact your physician for approval before discontinuing any prescription medication. Be sure to discuss all non-prescription medications with your physician.
Collection & Handling
Collection Instructions
24-hour urine collected in a polyethylene container with 25 mL 6N Hydrochloric Acid. It is important that the urine is refrigerated during the collection. The pH of the urine must be between 2-4.
15 mL 6N HCl is recommended for children less than 5 years old.
Handling Information
The final pH must be maintained from 2 – 4.
Additional Information
Provide 24 hour volume and date of collection.
Stability
| Refrigerated | 1 month |
|---|---|
| Frozen | 90 days |
Test Version
16-Nov-2022
Performance / Interpretation
Method
LC-MS/MS
Turnaround Time
8 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Volume | L |
|
||
| Creatinine/d | mmol/d |
|
||
| Vanillylmandelic Acid - Total | µmol/d |
|
mg/24 hr x 5.05 | |
| VMA/Creat Ratio | µmol/mmol cr |
|
||
Test Location
St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8
Test Version
16-Nov-2022
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| VMA | 7601Volume | L |
| 7637Creatinine/L | mmol/L | |
| 7602Creatinine/d | mmol/d | |
| 7603VMA | umol/d | |
| 7604VMA/Creat Ratio | umol/mmol cr |
Test Version
16-Nov-2022