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Aldosterone/Renin Ratio LC-MS/MS, Plasma

Test ID: ALRNA
Test
Specimen
Performance / Interpretation
Interface / Setup

Test

Method

LC-MS/MS

Report Includes

Aldosterone; Renin Activity

Specimens

Plasma (EDTA)

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

30-Aug-2022

Specimen

Specimens

Plasma (EDTA)

Collection Containers

Lavender top (EDTA)

Sample Volume

2 mL x 2

Patient Preparation

Patient should liberalize (not restrict) sodium intake. The following medications should be held for 4 weeks prior to testing or for as long as is clinically feasible: spironolactone, eplerenone, amiloride, triamterene, potassium-wasting diuretics, confectionary licorice, or chewing tobacco. Please refer to the 2016 Endocrine Society Practice Guidelines for more information (Funder et al., J Clin Endocrinol Metab 2016).

Collection & Handling

Collection Instructions

Collect blood midmorning, after the patient has been up (sitting, standing, or walking) for at least 2 hours and then seated for 5-15 minutes.

Handling Information

Separate plasma immediately and split into 2 aliquots. Freeze immediately. Indicate date and time of collection and whether the patient was supine or upright.

Stability

Ambient 6 hours
Refrigerated 4 hours
Frozen 30 days

Additional Stability Information

Prolonged refrigerated storage may lead to a false increase due to cryoactivation of prorenin to renin. If the specimen thaws, it is unsuitable for analysis.

Rejection Criteria

Specimen Not frozen

Test Version

30-Aug-2022

Performance / Interpretation

Method

LC-MS/MS

Turnaround Time

8 days

Results

Name Units Reference Range Conversion Factor
Aldosterone pmol/L
  • Upright
  • ≤ 9y: 80 - 2200
  • ≥ 10y: 70 - 660
  • Supine
  • < 6 days: 200 - 5100
  • 7 - 29 days: 140 - 4850
  • 1 - 12 months: 140 - 2500
  • 1 - 9 y: 140 - 1500
  • ≥ 10y: 30 - 415
Plasma Renin Activity ng/mL/hr
  • Upright
  • ≤6 days: <29
  • 1 - 6 weeks: <8.6
  • 6 weeks - 4 y: < 14
  • 4 - 13 y: <9.7
  • 13 - 16 y: < 5.4
  • ≥ 16 y: 0.36 - 4.0
  • Supine
  • ≥ 16 y: < 1.6
Aldosterone/Renin Activity Ratio pmol/L per ng/mL/hr
  • ARR: < 420

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

30-Aug-2022

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
ALRNA 2460Aldosterone pmol/L
64445Renin Activity, plasma ng/mL/hr
64444Ald/Renin Act Ratio

Test Version

30-Aug-2022