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Dolutegravir, Plasma

Test ID: DOLUTE P

Test

Aliases/Synonyms

Anti-retroviral; Antiretroviral; ARV; Integrase Inhibitor

Method

LC/MS

Report Includes

Dolutegravir

Specimens

Plasma
You must submit a completed ARV Requisition with the specimen. The requisition is mandatory as the information you provide is required in order to issue an interpretive report.
Specimens received at ICL by Wednesday will be delivered to the lab for the next analytical batch. Contact ICL Client Care for information regarding urgent testing required for dose adjustment.

Test Location

McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1

Test Version

23-Jun-2022

Specimen

Specimens

Plasma
You must submit a completed ARV Requisition with the specimen. The requisition is mandatory as the information you provide is required in order to issue an interpretive report.
Specimens received at ICL by Wednesday will be delivered to the lab for the next analytical batch. Contact ICL Client Care for information regarding urgent testing required for dose adjustment.

Collection Containers

Green Top (sodium heparin)

Sample Volume

1.0 mL

Specimen Comment

Avoid gel separator tubes. One aliquot is sufficient for multiple ARVs.

Pediatric Volume

0.2 mL

Collection & Handling

Collection Instructions

Blood should be drawn just prior to the next dose. If this is not possible, blood should be drawn 6 to 14 hours postdose for ARVs administered twice daily or 12 to 26 hours postdose for ARVs administered once daily. If malabsorption is suspected, a sample can be taken at the time when the concentration is expected to be at its maximum (Tmax). The Tmax varies between the different antiretrovirals but is generally 2 to 4 hours post-dose. One sample is sufficient even if more than one antiretroviral is to be measured.

Handling Information

Centrifuge the specimen (3000 x g for 5 minutes) within 6 hours of procurement. Store and send frozen.

Stability

Refrigerated 1 day
Frozen Months ≤-20°C

Test Version

23-Jun-2022

Performance / Interpretation

Method

LC/MS

Turnaround Time

24 days

Results

Name Units Reference Range Conversion Factor
Dolutegravir
An interpretive report will be issued. The results are interpreted taking into consideration all patient information provided including indication for TDM, concomitant medications, antiretroviral dose, intake with or without food, adherence and viral resistance. Interpretation details at external website.

Test Location

McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1

Test Version

23-Jun-2022

Interface / Setup

Test Version

23-Jun-2022