Anti-retroviral; Antiretroviral; ARV; Integrase Inhibitor
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Dolutegravir, Plasma
Test ID: DOLUTE P
Test
Aliases/Synonyms
Method
LC/MS
Report Includes
Dolutegravir
Specimens
Plasma
You must submit a completed ARV Requisition with the specimen. The requisition is mandatory as the information you provide is required in order to issue an interpretive report.
Specimens received at ICL by Wednesday will be delivered to the lab for the next analytical batch. Contact ICL Client Care for information regarding urgent testing required for dose adjustment.
You must submit a completed ARV Requisition with the specimen. The requisition is mandatory as the information you provide is required in order to issue an interpretive report.
Specimens received at ICL by Wednesday will be delivered to the lab for the next analytical batch. Contact ICL Client Care for information regarding urgent testing required for dose adjustment.
Test Location
McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1
Test Version
23-Jun-2022
Specimen
Specimens
Plasma
You must submit a completed ARV Requisition with the specimen. The requisition is mandatory as the information you provide is required in order to issue an interpretive report.
Specimens received at ICL by Wednesday will be delivered to the lab for the next analytical batch. Contact ICL Client Care for information regarding urgent testing required for dose adjustment.
You must submit a completed ARV Requisition with the specimen. The requisition is mandatory as the information you provide is required in order to issue an interpretive report.
Specimens received at ICL by Wednesday will be delivered to the lab for the next analytical batch. Contact ICL Client Care for information regarding urgent testing required for dose adjustment.
Collection Containers
Green Top (sodium heparin)
Sample Volume
1.0 mL
Specimen Comment
Avoid gel separator tubes. One aliquot is sufficient for multiple ARVs.
Pediatric Volume
0.2 mL
Collection & Handling
Collection Instructions
Blood should be drawn just prior to the next dose. If this is not possible, blood should be drawn 6 to 14 hours postdose for ARVs administered twice daily or 12 to 26 hours postdose for ARVs administered once daily. If malabsorption is suspected, a sample can be taken at the time when the concentration is expected to be at its maximum (Tmax). The Tmax varies between the different antiretrovirals but is generally 2 to 4 hours post-dose. One sample is sufficient even if more than one antiretroviral is to be measured.
Handling Information
Centrifuge the specimen (3000 x g for 5 minutes) within 6 hours of procurement. Store and send frozen.
Stability
| Refrigerated | 1 day |
|---|---|
| Frozen | Months ≤-20°C |
Test Version
23-Jun-2022
Performance / Interpretation
Method
LC/MS
Turnaround Time
24 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Dolutegravir |
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An interpretive report will be issued. The results are interpreted taking into consideration all patient information provided including indication for TDM, concomitant medications, antiretroviral dose, intake with or without food, adherence and viral resistance. Interpretation details at external website.
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Test Location
McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1
Test Version
23-Jun-2022
Interface / Setup
Test Version
23-Jun-2022