Due to ongoing labour disputes, Canada Post services will be suspended, which may impact some of our FIT and Integrative Laboratory Services (ILS) clients. Read more
Back to Test Catalogue

Metanephrines – Fractionated LC-MS/MS, 24 hr Urine

Test ID: METF U

Test

Aliases/Synonyms

Fractionated metanephrines, Free Metanephrine, Metanephrines Free, urine, NMN, urine, Normetanephrine, free, Normetanephrines, urine

Method

LC-MS/MS

Report Includes

Free Normetanephrine; Free Metanephrine; Free Normetanephrine, 24hr; Free Normetanephrine/Creatinine Ratio; Free Metanephrine, 24hr; Free Metanephrine/Creatinine Ratio; 3-Methoxytyamine; 3-Methoxytyramine, 24hr; 3-Methoxytyramine/Creatinine Ratio; Volume; Creatinine/L; Creatinine/d

Specimens

Urine (24 hr)

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

21-Dec-2023

Specimen

Specimens

Urine (24 hr)

Sample Volume

25 mL

Patient Preparation

Restrict caffeine, nicotine and alcohol for 24 hours prior to collection. Discontinue Methyldopa (Aldomet) at least 5 days prior to collection. Avoid reserpine, alpha methyldopa, levodopa, monoamine oxidase inhibitors.

Collection & Handling

Collection Instructions

Collect urine in a container with 25 mL 6 mol/L (6N) HCl. It is important that the urine is refrigerated during the collection.

Handling Information

The final pH of the urine must be 2.0 – 4.0. State 24 hour collection volume and collection date.

Stability

Refrigerated 1 month
Frozen >1 month

Test Version

21-Dec-2023

Performance / Interpretation

Method

LC-MS/MS

Turnaround Time

10 days

Results

Name Units Reference Range Conversion Factor
Volume L
Creatinine nmol/L
Creatinine/d mmol/d
Free Normetanephrine nmol/L
Free Metanephrine nmol/L
Free Normetanephrine, 24hr nmol/d
  • Male: <300
  • Female: <300
Free Normetanephrine/Creatinine Ratio nmol/mmol creatinine
  • <34
Free Metanephrine, 24 hour nmol/d
  • Male: <270
  • Female: <170
Free Metanephrine/Creatinine Ratio nmol/mmol creatinine
  • <31
3-Methoxytyamine nmol/L
3-Methoxytyramine, 24hr nmol/d
  • Male: <380
  • Female: <300
3-Methoxytyramine/Creatinine Ratio nmol/mmol creatinine
  • <45

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

21-Dec-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
METF U 63310Normetanephrine Uncalculated Free nmol/L
63311Metanephrine Uncalculated Free nmol/L
6331224h Normetanephrine Free nmol/d
63313Normet/Crt Ratio nmol/mmol creat
6331424h Metanephrine Free nmol/d
63315Met/Crt Ratio nmol/mmol creat
633163-Methoxytyamine Uncalculated nmol/L
633173-Methoxytyramine, 24h nmol/d
633183-Methoxy/Creat Ratio nmol/mmol creat
7601Volume L
7637Creatinine/L mmol/L
7602Creatinine/d mmol/d

Test Version

21-Dec-2023