Anti-MOG; MOG Antibodies; Neuromyelitis Optica (NMO) Antibodies; Anti-NMO; Anti-Aquaporin 4
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Neuromyelitis Optica Spectrum Disorder (NMOSD) Panel, Serum; test site SJH
Test ID: NMOG S
Test
Aliases/Synonyms
Method
Cell-Based Indirect Immunofluorescence
Report Includes
Aquaporin 4 Antibodies; Myelin-Oligodendrocyte Glycoprotein Antibodies (Anti-MOG)
Specimens
Serum
Clinical Utility
Many cases of Neuromyelitis Optica-spectrum disorders (NMOSD) are misdiagnosed as Multiple Sclerosis. As correct diagnosis is critical for prognosis, optimal treatment and prediction of relapse, initial testing for both Aquaporin 4 (AQP4) Antibodies and Myelin-Oligodendrocyte Glycoprotein (MOG) Antibodies is strongly recommended for new cases of NMOSD- see separate test listings. AQP4 antibodies are detected in about 80% of patients with NMO. Of these seronegative AQP-4 cases 7% will harbour MOG antibodies. Patients very rarely harbour both antibodies.
Test Location
St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5
Test Version
29-Aug-2024
Specimen
Specimens
Serum
Sample Volume
2.0 mL
Minimum Volume
1.0 mL
Collection & Handling
Handling Information
Separate as soon as possible. Store and send frozen.
Stability
| Ambient | 6 hours |
|---|---|
| Refrigerated | 14 days |
| Frozen | 60 days |
Test Version
29-Aug-2024
Performance / Interpretation
Method
Cell-Based Indirect Immunofluorescence
Turnaround Time
12 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Aquaporin 4 Antibodies |
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Results of 1+ to 4+ indicate the presence of this autoantibody in increasing titers
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| Myelin-Oligodendrocyte Glycoprotein Antibodies (Anti-MOG) |
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Low Positive (1:10): Positive at 1:10 dilution and Negative at 1:100 dilution, indicating an endpoint titre that is between 1:10 and 1:100.
Clear Positive (1:100): Positive at 1:10 dilution and Positive at 1:100 dilution, indicating an endpoint titre that is greater than or equal to 1:100. |
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Test Location
St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5
Test Version
29-Aug-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| NMOG S | 62782Anti Aquaporin 4 (NMO) | |
| 62783Anti MOG |
Test Version
29-Aug-2024