CRMP-5-IgG Western Blot
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Collapsin Response-Mediator Protein-5-IgG (CRMP-5-IgG) Western Blot, CSF
Test ID: CRMP CSF
Test
Method
Western Blot
Method Description
Western blot is performed on denatured full-length recombinant humancollapsin response-mediator protein-5 (CRMP-5), reduced and subjected to electrophoresis on 10% polyacrylamide gel. IgG is detected autoradiographically by enhanced chemiluminescence.(Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49[2]:146-154)
Report Includes
Specimens
CSF
Clinical Utility
This testing is recommended in cases of chorea, vision loss, cranial neuropathy and myelopathy.
Clinical Information at external website.
Test Version
9-Dec-2019
Specimen
Specimens
CSF
Sample Volume
3 mL
Minimum Volume
2 mL
Collection & Handling
Handling Information
Store and send frozen
Stability
| Ambient | 72 hours |
|---|---|
| Refrigerated | 28 days |
| Frozen | 28 days |
Rejection Criteria
| Hemolysis | Gross |
|---|---|
| Lipemia | Gross |
| Other | Grossly icteric |
Test Version
9-Dec-2019
Performance / Interpretation
Method
Western Blot
Method Description
Western blot is performed on denatured full-length recombinant humancollapsin response-mediator protein-5 (CRMP-5), reduced and subjected to electrophoresis on 10% polyacrylamide gel. IgG is detected autoradiographically by enhanced chemiluminescence.(Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49[2]:146-154)
Turnaround Time
10 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| CRMP-5-IgG Western Blot | None |
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References:
Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49(2):146?154. Cross SA, Salomao DR, Parisi JE, et al: Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol 2003;54:38?50 |
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Test Version
9-Dec-2019
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| CRMP CSF | 63136CRMP-5-IgG Western Blot, CSF | None |
Test Version
9-Dec-2019