Test Overview
Method
Competitive binding enzyme immunoassay
Analytical Platform
Roche Cobas 6000
Result Included
Tobramycin - Trough
Aliases/Synonyms
Aminoglycoside
Specimen
Specimen Type
SerumContainers
Preferred Containers
Red top (no additive)
Acceptable Containers
Gold top (clot activator & gel)
Volume
Sample Volume
1 mL
Collection & Handling
Collection Instructions
Collect immediately before next dose. Wait until the third dose before collecting samples for therapeutic monitoring.
Handling Information
Store and send frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 4 hours | 7 days | 30 days |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Hemolysis | Grossly |
| Icterus | Present |
Performance & Interpretation
Turnaround Time
2 days
Results
Name
Units
Reference Range
Conversion
-
Tobramycin - Troughmg/LFor traditional (conventional) dosing method:
Pre-dose: <2.0 mg/L for adults and pediatrics
Half-hour post-dose: 4.0 - 10.0 mg/L for adults ; 5.0 - 10.0 mg/L for pediatrics
For extended interval (once daily) dosing method:
Pre-dose <1.0 mg/L for adults
8 - 12 hours post-dose for adults and use nomogram for interpretation;
3 and 6 hours post-dose for pediatrics and use nomogram for interpretation.
Comment
Refer to guidelines for Aminoglycoside dosing at your institution.
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| TOBRAT | Tobramycin, Before dose | 2563 | mg/L |
Test Version
Last Updated
2023-08-23