Neuromyelitis Optica (NMO) Antibodies; Anti-NMO; Anti-Aquaporin 4; AQP4 Antibody
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Aquaporin 4 Antibodies (Anti-NMO), CSF
Test ID: AQP4 CSF
Test
Aliases/Synonyms
Method
Cell-Based Indirect Immunofluorescence
Report Includes
Aquaporin 4 Antibodies
Specimens
CSF
Clinical Utility
Many cases of Neuromyelitis Optica-spectrum disorders (NMOSD) are misdiagnosed as Multiple Sclerosis. As correct diagnosis is critical for prognosis, optimal treatment and prediction of relapse, initial testing for both Aquaporin 4 (AQP4) Antibodies and Myelin-Oligodendrocyte Glycoprotein (MOG) Antibodies is strongly recommended for new cases of NMOSD – see separate test listings. AQP4 antibodies are detected in about 80% of patients with NMO. Of these seronegative AQP-4 cases 7% will harbor MOG antibodies. Patients very rarely harbour both antibodies.
Test Location
St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5
Test Version
24-Dec-2019
Specimen
Specimens
CSF
Sample Volume
1 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Store and send frozen.
Stability
| Ambient | 6 hours |
|---|---|
| Refrigerated | 14 days |
| Frozen | 60 days |
Test Version
24-Dec-2019
Performance / Interpretation
Method
Cell-Based Indirect Immunofluorescence
Turnaround Time
12 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Aquaporin 4 Antibodies |
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Results of 1+ to 4+ indicate the presence of this autoantibody in increasing titers
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Test Location
St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5
Test Version
24-Dec-2019
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| AQP4 CSF | 62781Anti Aquaporin 4 (NMO) (CSF) |
Test Version
24-Dec-2019