Back to Test Catalogue

Enhanced Liver Fibrosis (ELF), Serum

Test ID: ELF S

Test

Aliases/Synonyms

ELF Score

Method

Chemiluminescent Immunoassay

Method Description

The ELF score is based on the combined quantitative measurements of Hyaluronic acid, N-terminal propeptide type III procollagen (PIIINP) and Tissue inhibitor of matrix metalloproteinase 1 (TIMP-1).

Report Includes

Enhanced Liver Fibrosis (ELF) Score

Specimens

Serum

Clinical Utility

The ELF (Enhanced Liver Fibrosis) test is indicated, with other laboratory results and clinical evaluations, to assess the severity of liver fibrosis in patients with signs, symptoms, or risk factors of chronic liver disease.

Test Version

30-Sep-2025

Specimen

Specimens

Serum

Collection Containers

Gold top (clot activator & gel)

Sample Volume

1.0 mL

Minimum Volume

0.5 mL

Patient Preparation

Biotin supplementation exceeding 5000 mcg/day may skew analytical results. Discontinue supplementation 72 hours prior to sample collection.

The fluorescein used in retinal angiography can persist in the bloodstream and may interfere with analytical results. Wait at least 72 hours after the procedure before collecting the sample.

Collection & Handling

Handling Information

Spin and transfer serum to polypropylene transfer vial. Store and send frozen.

Stability

Ambient 2 days
Refrigerated 7 days
Frozen 12 months

Rejection Criteria

Hemolysis Present

Test Version

30-Sep-2025

Performance / Interpretation

Method

Chemiluminescent Immunoassay

Method Description

The ELF score is based on the combined quantitative measurements of Hyaluronic acid, N-terminal propeptide type III procollagen (PIIINP) and Tissue inhibitor of matrix metalloproteinase 1 (TIMP-1).

Turnaround Time

8 days

Results

Name Units Reference Range Conversion Factor
Enhanced Liver Fibrosis (ELF) Score
  • < 9.8 ELF score ranges and associated risk of disease progression (development of cirrhosis or liver-related events):
  • Lower: <9.80
  • Mid: 9.80 to 11.29
  • Higher: ≥11.30
The ELF score is based on the combined quantitative measurements of hyaluronic acid, amino terminal propeptide of type III procollagen and tissue inhibitor of matrix metalloproteinase 1.

Biotin supplementation exceeding 5000 mcg/day may skew analytical results. Discontinuing supplementation is recommended 72 hours prior to sample collection.

The fluorescein used in retinal angiography can persist in the bloodstream and may interfere with analytical results. It is recommended to wait at least 72 hours after the procedure before collecting the sample.

Test Version

30-Sep-2025

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
ELF S 66242ELF

Test Version

30-Sep-2025