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Test ID:
APNA
Paraneoplastic Autoantibodies Panel (LRC), Serum
Test Overview
Clinical Utility
Anti-neuronal antibodies are used as an aid in the diagnosis of neurologic syndromes. These antibodies are detected in the serum and CSF of a majority of patients with typical paraneoplastic syndromes and are not present in normal individuals.
Method
Immunoblot
Analytical Platform
Euroimmun EuroBlot Master 44
Result Included
Anti-Neuronal Antibodies Type 1 (Anti-Hu); Anti-Neuronal Antibodies Type 2 (Anti-Ri); PCA Type 1 (Anti-Yo); Anti-Tr (DNER); Anti-GAD65; Anti-Zic 4; Anti-TITIN; Anti-SOX1; Anti-Recoverin; Anti-PMA2 (Ma2/Ta); Anti-CV2; Anti-Amphiphysin; APNA Comment
Specimen
Specimen Type
SerumImportant Note: TEST ID APNA
Non-interfaced clients should specify the Test ID APNA when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: Similar tests are offered by other ICL supplier labs:
Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum
Volume
Sample Volume
1 mL
Collection & Handling
Handling Information
Store and send cold or frozen.
Stability
| Refrigerated | Frozen |
|---|---|
| 7 days | >7 days |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Hemolysis | Gross |
| Lipemia | Gross |
| Specimen | Gross microbial contamination |
Performance & Interpretation
Turnaround Time
15 days
Results
Name
Units
Reference Range
Conversion
-
Anti-Neuronal Antibodies Type 1 (Anti-Hu)Negative
-
Anti-Neuronal Antibodies Type 2 (Anti-Ri)Negative
-
PCA Type 1 (Anti-Yo)Negative
-
Anti-Tr (DNER)Negative
-
Anti-GAD65Negative
-
Anti-Zic 4Negative
-
Anti-TITINNegative
-
Anti-SOX1Negative
-
Anti-RecoverinNegative
-
Anti-PMA2 (Ma2/Ta)Negative
-
Anti-CV2Negative
-
Anti-AmphiphysinNegative
-
APNA Comment
Comment
Results in the borderline range will be reported with the comment "Results in the borderline range should be evaluated as increased but negative".
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| APNA | ANNA1 (ANTI-HU) | 28626 | |
| ANNA2 (ANTI-RI) | 28627 | ||
| PCA1 (ANTI-YO) | 28625 | ||
| ANTI-TR (DNER) | 64320 | ||
| ANTI-GAD65 | 64321 | ||
| ANTI-ZIC 4 | 64322 | ||
| ANTI-TITIN | 64323 | ||
| ANTI-SOX1 | 64324 | ||
| ANTI-RECOVERIN | 64325 | ||
| ANTI-PMA2 (MA2/TA) | 64326 | ||
| ANTI-CV2 | 64327 | ||
| ANTI-AMPHIPHYSIN | 64328 | ||
| APNA COMMENT | 64331 |
Test Version
Last Updated
2023-03-06