Comprehensive Autoimmune Encephalitis Panel (LHSC) , Serum

Test Overview

Clinical Utility

A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.

Method

Various

Method Description

Cell-based assay (CBA) and tissue indirect immunofluorescence (TIIF) assay for autoimmune encephalitis antibodies (reported based on CBA).
Immunoblot and tissue indirect immunofluorescence (TIIF) assay for paraneoplastic antibodies (reported based on immunoblot).
ELISA and immunoblot for Anti-GAD65.
Each sample will also be screened for neural antibodies based on research use-only TIIF.

Result Included

Autoimmune Encephalitis Antibodies:; Anti-NMDAR; Anti-LGI1; Anti-CASPR2; Anti-AMPAR1/R2; Anti-GABARB1/B2; Anti-DPPX
Paraneoplastic Antibodies:Anti-Hu (ANNA-1); Anti-Ri (ANNA-2); Anti-Yo (PCA-1); Anti-Amphiphysin; Anti-CV2 (CRMP5); Anti-Ma2/Ta (PNMA2); Anti-Tr (DNER); Anti-Zic4; Anti-Recoverin; Anti-Titin; Anti-SOX1;
Other Antibody: Anti-GAD65
Research-only Neural Antibodies:; Anti-GFAP; Anti-mGluR1; Anti-NIF; Anti-Neurochondrin; ANNA-3; PCA-2/Anti-MAP1B; Anti-AP3B2; Anti-PDE10A; Anti-KLHL11; Anti-ITPR1; Anti-GRAF

Aliases/Synonyms

Paraneoplastic antibodies

Specimen

Specimen Type

Serum

Paraneoplastic Antibodies included in this Panel may be ordered on their own: Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma

Containers

Collection Containers

Gold top (SST); Red top (no additive)

Volume

Sample Volume

1 mL

Collection & Handling

Handling Information

Store and send cold or frozen.

Stability

Refrigerated	Frozen
14 days	30 days

Performance & Interpretation

Turnaround Time

9 days

Results

Various

Negative
Anti-GAD65 ELISA

IU/mL

≤ 5

Referral Location

Canada

Interface & Setup

HL7 Interface Codes

Order Code	Result Name	Result Codes
AEP SP	Anti-AMPAR1/R2 CBA,Serum	63490
	Anti-CASPR2 CBA,Serum	63491
	Anti-DPPX CBA,Serum	63492
	Anti-GABARB1/B2 CBA,Serum	63493
	Anti-LGI1 CBA,Serum	63494
	Anti-NMDAR CBA,Serum	63495
	Anti-Amphiphysin Immunoblot,Serum	63496
	Anti-CV2 Immunoblot,Serum	63497
	Anti-GAD65 Immunoblot,Serum	63498
	Anti-Hu Immunoblot,Serum	63499
	Anti-Ma2:Ta Immunoblot,Serum	63500
	Anti-SOX1 Immunoblot,Serum	63501
	Anti-Recoverin Immunoblot,Serum	63502
	Anti-Ri Immunoblot,Serum	63503
	Anti-Titin Immunoblot,Serum	63504
	Anti-Tr (DNER) Immunoblot,Serum	63505
	Anti-Yo Immunoblot,Serum	63506
	Anti-Zic4 Immunoblot,Serum	63507
	Anti-GAD65 Elisa,Serum	63508
	Antibody Result,Serum	63509
	Research Based Antibody Scr.,TIIF,Serum	63510

Test Version

Last Updated

2026-03-17