Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma
Test Overview
Clinical Utility
A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.
Method
Various
Analytical Platform
Immunoblot: EUROBlotOne
Method Description
Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.
Result Included
Anti-Amphiphysin; Anti-CV2; Anti-GAD65; Anti-Hu; Anti-Ma2:Ta; Anti-Recoverin; Anti-Ri; Anti-SOX1; Anti-Titin; Anti-Tr (DNER); Anti-Yo; Anti-Zic4
Specimen
Specimen Type
SerumPlasma
Important Note: TEST ID PNPA SP
Non-interfaced clients should specify the Test ID PNPA SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), Serum.
A similar test is offered by another ICL supplier lab:
Paraneoplastic Autoantibodies Panel (LRC), Serum
Containers
Preferred Containers
Gold top (clot activator & gel); Red top (no additive)
Acceptable Containers
Lavender top (EDTA); Green top (lithium or sodium heparin); Blue top (3.2% buffered citrate)
Volume
Sample Volume
2.0 mL
Minimum Volume
0.5 mL
Pediatric
Volume
0.5 mL
Collection & Handling
Handling Information
Store and send cold or frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| Unacceptable | 14 days | 30 days |
Performance & Interpretation
Turnaround Time
17 days
Results
-
Anti-Amphiphysin ImmunoblotNegative
-
Anti-CV2 ImmunoblotNegative
-
Anti-GAD65 ImmunoblotNegative
-
Anti-Hu ImmunoblotNegative
-
Anti-Ma2:Ta ImmunoblotNegative
-
Anti-Recoverin ImmunoblotNegative
-
Anti-Ri ImmunoblotNegative
-
Anti-SOX1 ImmunoblotNegative
-
Anti-Titin ImmunoblotNegative
-
Anti-Tr (DNER) ImmunoblotNegative
-
Anti-Yo ImmunoblotNegative
-
Anti-Zic4 ImmunoblotNegative
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| Multiple | HL7 codes | 0 |
Test Version
Last Updated
2024-07-25