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Back to Test Catalogue
Test ID: PNPA CSF

Paraneoplastic Antibodies Expanded Panel (LHSC), CSF

Test Overview

Clinical Utility

A clinical diagnosis should not be made solely based on a neural antibody result; results should be interpreted in the context of the patients clinical presentation and other ancillary test findings to ensure accurate diagnosis.

Method

Various

Analytical Platform

Immunoblot: EUROBlotOne

Method Description

Immunoblot
Positive anti Hu, Yo, Ri, amphiphysin, CV2, Ma2, SOX-1, Zic4 and Tr (DNER) by immunoblot will be reflexed to tissue indirect immunofluorescence (TIIF) assay (reported based on immunoblot).
Positive anti-GAD65 by immunoblot will be reflexed to GAD65 ELISA. (Please note that GAD65 immunoblot is not optimal to screen for Anti-GAD65. If interested in testing for Anti-GAD65 specifically, consider alternative test methodology such as GAD65 ELISA.)
Anti-titin and antirecoverin antibodies are determined by immunoblot only.

Result Included

Anti-Amphiphysin; Anti-CV2; Anti-GAD65; Anti-Hu; Anti-Ma2:Ta; Anti-Recoverin; Anti-Ri; Anti-SOX1; Anti-Titin; Anti-Tr (DNER); Anti-Yo; Anti-Zic4

Specimen

Specimen Type

CSF
Submission of a concurrent serum is recommended (billed separately): Paraneoplastic Antibodies Expanded Panel (LHSC), Serum/Plasma

Important Note: TEST ID PNPA CSF
Non-interfaced clients should specify the Test ID PNPA CSF when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting - please refer to the notes below.
Alternate/Similar Laboratory Services: This laboratory also offers a panel that includes Autoimmune Encephalitis Antibodies and Paraneoplastic Antibodies: Comprehensive Autoimmune Encephalitis Panel (LHSC), CSF .

Volume

Sample Volume

2.0 mL

Minimum Volume

0.5 mL

Pediatric

Volume

0.5 mL

Collection & Handling

Handling Information

Store and send cold or frozen.

Stability

Ambient Refrigerated Frozen
Unacceptable 14 days 30 days

Performance & Interpretation

Turnaround Time

17 days

Results

Name
Units
Reference Range
Conversion
  1. Anti-Amphiphysin Immunoblot
    Negative
  2. Anti-CV2 Immunoblot
    Negative
  3. Anti-GAD65 Immunoblot
    Negative
  4. Anti-Hu Immunoblot
    Negative
  5. Anti-Ma2:Ta Immunoblot
    Negative
  6. Anti-Recoverin Immunoblot
    Negative
  7. Anti-Ri Immunoblot
    Negative
  8. Anti-SOX1 Immunoblot
    Negative
  9. Anti-Titin Immunoblot
    Negative
  10. Anti-Tr (DNER) Immunoblot
    Negative
  11. Anti-Yo Immunoblot
    Negative
  12. Anti-Zic4 Immunoblot
    Negative

Interface & Setup

HL7 Interface Codes

Order Code Result Name Result Codes Units
Multiple HL7 codes 0

Test Version

Last Updated

2024-07-25