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Test ID:
ICAB
Islet Cell Antibodies with Reflex Titer, Serum
Test Overview
Clinical Utility
Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.
Method
Indirect Immunofluorescence Assay (IFA)
Result Included
Islet Cell Antibody Screen; Islet Cell Antibody Titer
Specimen
Specimen Type
SerumVolume
Sample Volume
2.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Store and send cold.
Additional Information
If Islet Cell Antibody Screen is positive, Islet Cell Antibody Titer will be performed at an additional fee.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 48 hours | 14 days | 6 months |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Hemolysis | Gross |
| Lipemia | Present |
| Other | Icteric |
Performance & Interpretation
Turnaround Time
13 days
Results
Name
Units
Reference Range
Conversion
-
Islet Cell Antibody ScreenQualitative TestNegative
-
Islet Cell Antibody TiterJDF Units<5
Referral Location
Out-of-Country
Test Version
Last Updated
2025-02-10