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Islet Cell Antibodies with Reflex Titer, Serum

Test ID: ICAB

Test

Method

Immunofluorescence Assay (IFA)

Report Includes

Islet Cell Antibody Screen; Islet Cell Antibody Titer

Specimens

Serum

Clinical Utility

Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.

Test Location

Quest Diagnostics, California USA

Test Version

20-Feb-2024

Specimen

Specimens

Serum

Sample Volume

2.0 mL

Minimum Volume

0.5 mL

Collection & Handling

Handling Information

Store and send cold.

Stability

Ambient 48 hours
Refrigerated 14 days
Frozen 6 months

Rejection Criteria

Hemolysis Gross
Lipemia Present
Other Icteric

Test Version

20-Feb-2024

Performance / Interpretation

Method

Immunofluorescence Assay (IFA)

Turnaround Time

13 days

Results

Name Units Reference Range Conversion Factor
Islet Cell Antibody Screen Qualitative Test
  • Negative
Islet Cell Antibody Titer JDF Units
  • <1.25

Test Location

Quest Diagnostics, California USA

Test Version

20-Feb-2024

Interface / Setup

Test Version

20-Feb-2024