Test Overview
Clinical Utility
Histamine is a mediator of the allergic response. Histamine release causes itching, flushing, hives, vomiting, syncope, and even shock. In addition, some patients with gastric carcinoids may exhibit high concentrations of histamine.
Method
Immunoassay (IA)
Result Included
Histamine
Specimen
Specimen Type
Urine (24 hr)Containers
Collection Containers
Sterile Container
Volume
Sample Volume
4 mL
Minimum Volume
2 mL
Patient Preparation
Patient should avoid direct sunlight. Restrict histamine-rich foods (cheese, wine, red meats, spinach and tomatoes), allergy causing drugs, antihistamines, oral corticosteroids and substances which block H2 receptors for at least 24 hours prior to and during collection.
Collection & Handling
Collection Instructions
Collect with 10 mL 6N HCl or with no preservative.
Handling Information
Store and send cold or frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 2 days | 14 days | 14 days |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Hemolysis | Moderate |
Performance & Interpretation
Turnaround Time
10 days
Results
Name
Units
Reference Range
Conversion
-
Histaminemg/d0.006 - 0.131
-
Creatinineg/d<3 y: Not established
3 - 8 y: 0.10 - 0.30
9 - 12 y: 0.20-1.40
13 - 17 y: 0.40-1.90
>17 y: 0.50 - 2.15
Referral Location
Out-of-Country
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| HISTA U | TOTAL VOLUME | 64479 | mL |
| HISTAMINE, 24 HR URINE | 38810 | mg/24 h |
Test Version
Last Updated
2025-03-11