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Drug Screen, Serum

Test ID: DS
Test
Specimen
Performance / Interpretation
Interface / Setup

Test

Aliases/Synonyms

Acetaminophen; Acetone; Barbiturates, Screen; Benzodiazepines, Screen; Ethanol; Isopropanol; Methanol; Salicylate; Tricyclic Antidepressants, Screen

Method

Various

Method Description

Immunoassay: Acetaminophen, Barbiturates screen, Benzodiazepines screen, Tricyclic Antidepressants screen
Enzymatic/Colorimatric: Salicylate
GC-FID: Acetone, Ethanol, Isopropanol, Methanol

Report Includes

Acetaminophen; Salicylate; Acetone; Isopropanol; Methanol; Barbiturates, Screen; Benzodiazepines, Screen; Tricyclic Antidepressants, Screen

Specimens

Serum; Avoid gel separator tubes.

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

17-Mar-2023

Specimen

Specimens

Serum; Avoid gel separator tubes.

Collection Containers

Red top (no additive)

Sample Volume

2 mL

Minimum Volume

2 mL

Specimen Comment

Avoid gel separator tubes.

Collection & Handling

Handling Information

Store and send frozen.

Additional Information

Provide list of prescribed drugs and/or reason for analysis e.g. monitoring, compliance or the name of the suspected drug.

Stability

Ambient 24 hours
Refrigerated 7 days
Frozen 28 dyas

Test Version

17-Mar-2023

Performance / Interpretation

Method

Various

Method Description

Immunoassay: Acetaminophen, Barbiturates screen, Benzodiazepines screen, Tricyclic Antidepressants screen
Enzymatic/Colorimatric: Salicylate
GC-FID: Acetone, Ethanol, Isopropanol, Methanol

Turnaround Time

2 days

Results

Name Units Reference Range Conversion Factor
Acetaminophen µ mol/L
  • 0 - 66
Results > 66 µmol/L : Potentially toxic acetaminophen level depending on clinical context and time since last ingestion. Please refer to Rumack-Matthew nomogram if applicable (i.e., in suspected single acute ingestion)
Results > 660 µmol/L: Suggests toxicity in patients presenting approx. 6 hours following single acute acetaminophen ingestion. Please refer to Rumack-Matthew nomogram.
Acetone mmol/L
  • Ketoacidosis: 1.7 - 12.0
Barbiturates, screen
  • Not Detected
Cut-off: 500 ng/mL
Benzodiazepines, screen
  • Not Detected
Cut-off: 100 ng/mL
Ethanol mmol/L
  • Toxic: > 39.0
  • Impairment: 11.0 - 22.0
  • CNS depression: > 22.0
  • Fatalities:> 87.0
  • Legal limit: 17.4
Isopropanol mmol/L
  • Toxic > 6.7
Salicylate mmol/L
  • Toxic: > 2.20
  • Antipyretic/Analgesic: 0.15 - 0.72
  • Anti-inflammatory: 1.00 - 2.00 mmol/L
Tricyclic Antidepressants, screen Not Detected
Cut-off: 300 ng/mL

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

17-Mar-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
DS 9368Tricyclics Scn
9308Salicylate mmol/L
9313Barbiturates Scn
9306Acetaminophen umol/L
9357Methanol mmol/L
9351Ethanol mmol/L
9354Isopropanol mmol/L
9348Acetone mmol/L
9371Benzodiazepine Scn

Test Version

17-Mar-2023