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Doxepin and Metabolite, Serum/Plasma

Test ID: DOX
Test
Specimen
Performance / Interpretation
Interface / Setup

Test

Method

LC-MS/MS

Report Includes

Doxepin; Desmethyldoxepin; Doxepin + Desmethyldoxepin

Specimens

Avoid gel separator tubes; Serum; Plasma (EDTA)

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

14-Oct-2022

Specimen

Specimens

Avoid gel separator tubes; Serum; Plasma (EDTA)

Sample Volume

3 mL

Specimen Comment

Avoid gel separator tubes.

Collection & Handling

Collection Instructions

Collect trough specimen (i.e. collected within 1 hours prior to next dose or at least 12 hours after last dose.)

Handling Information

Separate as soon as possible.

Stability

Ambient 5 days
Refrigerated 2 weeks
Frozen 6 months

Rejection Criteria

Specimen Gel-separator tube

Test Version

14-Oct-2022

Performance / Interpretation

Method

LC-MS/MS

Turnaround Time

5 days

Results

Name Units Reference Range Conversion Factor
Doxepin ng/mL
  • No therapeutic range for Doxepin alone
Desmethyldoxepin ng/mL
  • No therapeutic range for Desmethyldoxepin alone
Doxepin + Desmethyldoxepin, Total ng/mL
  • Therapeutic: 50 - 150
  • Toxic: > 300
(Effective 18-Oct-2022)

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

14-Oct-2022

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
DOX 7573Doxepin ng/mL
7574Desmethyl Doxepin ng/mL
7575Combined Metabolite ng/mL

Test Version

14-Oct-2022