5HIAA
5-Hydroxyindole Acetic Acid (5-HIAA), Random Urine
Test
Aliases/Synonyms
Method
LC-MS/MS
Report Includes
Creatinine; 5-Hydroxyindole Acetic Acid; 5-Hydroxyindole Acetic Acid/Creatinine Ratio
Specimens
Urine (Random)
Test Location
St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8
Test Version
16-Nov-2022
Specimen
Specimens
Urine (Random)
Collection Containers
Mid-stream urine container
Sample Volume
10 mL
Patient Preparation
The following foods and medications should be avoided for three (3) days prior to the collection of urine, and during the collection of the sample:
Foods containing high hydroxyindole concentrations (e.g. aubergines, avocados, bananas, black- and red-currants, kiwi, gooseberries, melons, tomatoes, plums, pineapples and walnuts) as well as Glyceryl Guaiacolate (an ingredient in some cough medicines) can increase urinary 5-HIAA excretion. Pregnancy and sleep deprivation can also result in raised 5-HIAA excretion.
Medications and drugs such as Levodopa, Methyldopa, Monoamine Oxidase Inhibitors, Ethanol, Imipramine, Isoniazid, Reserpine and p-Chlorophenylalanine can reduce 5- HIAA production. Others, such as Acetanilide, Phenacetin, Methocarbamol, Cisplatin, Fluorouracil, Melphalan and Rauwolfia Alkaloids can increase urinary 5-HIAA, as can 5- Hydroxytryptophan, which is used to treat depression and is available over-the-counter.
Collection & Handling
Handling Information
Acidify sample within 24 hours of collection using 6N HCl to a pH of less than 4 (just one or 2 drops).
Additional Information
Indicate Random.
Stability
Refrigerated | 1month |
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Frozen | > 1 month |
Rejection Criteria
Specimen | pH > 5.0 |
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Test Version
16-Nov-2022
Performance / Interpretation
Method
LC-MS/MS
Turnaround Time
10 days
Results
Name | Units | Reference Range | Conversion Factor | |
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Creatinine | mmol/L |
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5-Hydroxyindole Acetic Acid | µmol/L |
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5-Hydroxyindole Acetic Acid/Creatinine Ratio | µmol/mmol Creatinine |
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Test Location
St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8
Test Version
16-Nov-2022
Interface / Setup
HL7 Interface Codes
Order Code | Result Codes | Units |
---|---|---|
5HIAARU | 28004Creatinine Rand Urine | mmol/L |
280105-HIAA Random | umol/L | |
280135HIAA Creat Ratio | umol/mmol crea |
Test Version
16-Nov-2022