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Clozapine and Norclozapine, Plasma

Test ID: CLOZA

Test

Aliases/Synonyms

Clozaril

Method

LC-MSD

Report Includes

Clozapine; Norclozapine

Specimens

Avoid gel separator tubes; Plasma (EDTA); Plasma (Li Heparin); Serum

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

8-Nov-2023

Specimen

Specimens

Avoid gel separator tubes; Plasma (EDTA); Plasma (Li Heparin); Serum

Collection Containers

Preferred

Plasma (EDTA lavender top)

Acceptable

Plasma (green top Li Heparin); Serum (red top)

Sample Volume

1 mL

Minimum Volume

0.5 mL

Specimen Comment

Avoid gel separator tubes.

Collection & Handling

Handling Information

Store and send frozen.

Test Version

8-Nov-2023

Performance / Interpretation

Method

LC-MSD

Turnaround Time

7 days

Results

Name Units Reference Range Conversion Factor
Clozapine nmol/L
  • Minimum effective concentration: 1070
  • Significant CNS toxicity e.g. generalized tonic-clonic seizure may be associated with concentrations above 3100
µg/L x 3.06
Norclozapine nmol/L
  • Therapeutic ranges not available.
µg/L x 3.19

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

8-Nov-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
CLOZA 20707Clozapine,S nmol/L
20708Norclozapine,S nmol/L

Test Version

8-Nov-2023