Test Overview
Clinical Utility
Toxic effects are centrally mediated (CNS) and concentration dependent.
Hematological effects, agranulocytosis, are concentration independent.
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
Clozapine; Norclozapine
Aliases/Synonyms
Clozaril
Specimen
Specimen Type
Avoid gel separator tubes
Plasma (EDTA)
Plasma (Li Heparin)
Serum
Containers
Preferred Containers
Plasma (EDTA lavender top)
Acceptable Containers
Plasma (green top Li Heparin); Serum (red top)
Volume
Sample Volume
1 mL
Minimum Volume
0.5 mL
Specimen Comment
Avoid gel separator tubes.
Collection & Handling
Handling Information
Store and send frozen.
Performance & Interpretation
Turnaround Time
7 days
Results
Name
Units
Reference Range
Conversion
-
Clozapinenmol/LMinimum effective concentration: 1070
Laboratory Alert: > 3100µg/L x 3.06 -
Norclozapinenmol/LTherapeutic ranges not available.µg/L x 3.19
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| CLOZA | Clozapine,S | 20707 | nmol/L |
| Norclozapine,S | 20708 | nmol/L |
Test Version
Last Updated
2024-01-15