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Neurofilament Light Chain (NfL), Serum/Plasma

Test ID: NFLC SP
Test
Specimen
Performance / Interpretation
Interface / Setup

Test

Method

Electrochemiluminescent immunoassay (ECLIA)

Platform

Roche

Report Includes

Neurofilament Light Chain

Specimens

Serum; Plasma (Li heparin);

Important Note: TEST ID NFLC SP
Non-interfaced clients should specify the Test ID TEST ID NFLC SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.
Similar testing is available for clinical use at The Ottawa Hospital: Neurofilament Light Chain (NfL), Serum

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Specimen

Specimens

Serum; Plasma (Li heparin);

Important Note: TEST ID NFLC SP
Non-interfaced clients should specify the Test ID TEST ID NFLC SP when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.
Similar testing is available for clinical use at The Ottawa Hospital: Neurofilament Light Chain (NfL), Serum

Collection Containers

Preferred

Gold top (clot activator & gel)

Acceptable

Green top (lithium heparin)

Sample Volume

1.0 mL

Minimum Volume

0.4 mL

Patient Preparation

High dose biotin supplementation may interfere with analysis – patients should stop biotin consumption at least 72 hours prior to the collection of a sample.

Collection & Handling

Handling Information

Store and send frozen.

Stability

Ambient 1 day
Refrigerated 14 days
Frozen 3 years

Additional Stability Information

Stable up to 3 freeze-thaw cycles.

Performance / Interpretation

Method

Electrochemiluminescent immunoassay (ECLIA)

Platform

Roche

Turnaround Time

8 days

Results

Name Units Reference Range Conversion Factor
Neurofilament Light Chain pg/mL
  • 0 to 4 y< 1.97
  • 5 to 9 y< 1.64
  • 15 to 19 y< 1.60
  • 20 to 29 y< 1.65
  • 30 to 39 y< 1.88
  • 40 to 49 y< 2.14
  • 50 to 59 y< 3.79
  • 60 to 69 y< 4.62
  • 70 to 79 y< 7.65
  • > 79 y< 11.56
Serum NfL levels in healthy individuals are about 2.5% of the levels in CSF and correlate highly with the concentrations in CSF.

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
NFLC SP 65355Neurofilament Light Chain pg/mL