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Test ID: ITRAEOR SP

Itraconazole LC-MS/MS, Serum/Plasma

Test Overview

Method

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Result Included

Itraconazole; Hydroxyitraconazole

Specimen

Specimen Type

Avoid gel separator tubes
Serum
Plasma

Containers

Preferred Containers

Green top (sodium heparin)

Acceptable Containers

Red top (no additive)

Volume

Sample Volume

1.0 mL

Minimum Volume

0.5 mL

Collection & Handling

Collection Instructions

Collect immediately before next scheduled dose or at least 12 hours after last dose.

Handling Information

Store and send frozen.

Stability

Refrigerated	Frozen
1 day	> 1 day

Rejection Criteria

Criteria	Specification
Specimen	Collected in gel-separator tube

Performance & Interpretation

Turnaround Time

10 days

Results

Itraconazole

µg/mL

Therapeutic: > 0.5
Toxic: > 5.0
Hydroxyitraconazole

µg/mL

None

Comment

No therapeutic range has been established for hydroxyitraconazole; activity and serum concentrations are similar to parent drug. Some studies suggest hydroxyitraconazole levels are slightly higher than itraconazole levels, with a HO-itraconazole:itraconazole ratio 1.1 - 2.5. Other studies suggest the combined itraconazole and HO-itraconazole concentration should be >1.5 ug/mL.

Referral Location

Canada

Interface & Setup

HL7 Interface Codes

Order Code	Result Name	Result Codes	Units
ITRAEOR SP	Itraconazole	65007	ug/mL
	Hydroxyitraconazole	65751	ug/mL

Test Version

Last Updated

2024-11-15