Infliximab with Reflex Antibodies, Serum
Test Overview
Clinical Utility
Infliximab Antibodies will only be tested (and billed) when the measured Infliximab concentration is subtherapeutic (Infliximab ≤ 5 µg/mL).
Method
Various
Method Description
Infliximab Quantitation: Mass Spectrometry
Infliximab Antibodies: semi-quantitative ELISA (Immunodiagnostik)
Result Included
Infliximab; Infliximab Antibodies
Aliases/Synonyms
Remicade; Inflectra; Renflexis
Specimen
Specimen Type
SerumContainers
Preferred Containers
Red top (no additive)
Acceptable Containers
Gold Top (clot activator and gel)
Volume
Sample Volume
3 mL
Minimum Volume
2 mL
Collection & Handling
Collection Instructions
Collect trough specimen immediately prior to the next infusion.
Handling Information
Please indicate date/time of last infusion. Store and send cold or frozen.
Additional Information
Date/time of last infusion is requested to facilitate appropriate interpretation and to assist the test provider in troubleshooting unusual findings and in support of appropriate utilization (e.g., collection at true trough).
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 7 days | 7 days | 28 days |
Performance & Interpretation
Turnaround Time
9 days
Results
-
Infliximabµg/mLTherapeutic: > 5.0 (see comment below)
Comment
When infliximab trough concentration is greater than 5.0 µg/mL, clinically relevant antibodies to infliximab are unlikely and reflex antibody testing is not performed.
-
Infliximab AntibodiesNot detected
Comment
Interpretation
1+: Antibodies to infliximab detected, clinical significance uncertain.
2+: Antibodies to infliximab detected at significant concentrations.
3+: Antibodies to infliximab detected at significant concentrations.
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| Multiple | HL7 codes | 0 |
Test Version
Last Updated
2023-10-18