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Amitriptyline and Nortriptyline, Serum/Plasma

Test ID: AMIT

Test

Method

LC-MS/MS

Report Includes

Amitriptyline; Nortriptyline; Amitriptyline + Nortriptyline

Specimens

Avoid gel separator tubes; Serum; Plasma (EDTA)

Test Location

ON, CA

Test Version

25-Aug-2022

Specimen

Specimens

Avoid gel separator tubes; Serum; Plasma (EDTA)

Sample Volume

3 mL

Specimen Comment

Avoid gel separator tubes.

Collection & Handling

Collection Instructions

Collect trough specimen (i.e. collected within 1 hours prior to next dose or at least 12 hours post-dose.)

Handling Information

Separate within 2 hours.

Stability

Ambient 5 days
Refrigerated 2 weeks
Frozen 6 months

Rejection Criteria

Container Gel-separator tube

Test Version

25-Aug-2022

Performance / Interpretation

Method

LC-MS/MS

Turnaround Time

5 days

Results

Name Units Reference Range Conversion Factor
Amitriptyline ng/mL
  • No therapeutic range for Amitriptyline alone
Nortriptyline ng/mL
  • No therapeutic range for Nortriptyline alone
Amitriptyline + Nortriptyline ng/mL
  • Therapeutic: 0.45 - 0.90
  • Toxic: ≥1.80

Test Location

ON, CA

Test Version

25-Aug-2022

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
AMIT 7566Amitriptyline ng/mL
7567Nortriptyline ng/mL
7568Combined Metabolite ng/mL

Test Version

25-Aug-2022