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Test ID:
AMIT
Amitriptyline and Nortriptyline, Serum/Plasma
Test Overview
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
Amitriptyline; Nortriptyline; Amitriptyline + Nortriptyline, Total
Specimen
Specimen Type
Avoid gel separator tubesSerum
Plasma (EDTA)
Volume
Sample Volume
3 mL
Specimen Comment
Avoid gel separator tubes.
Collection & Handling
Collection Instructions
Collect trough specimen (i.e. collected within 1 hours prior to next dose or at least 12 hours post-dose.)
Handling Information
Separate within 2 hours.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 5 days | 2 weeks | 6 months |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Gel-separator tube |
Performance & Interpretation
Turnaround Time
5 days
Results
Name
Units
Reference Range
Conversion
-
Amitriptylineng/mLNo therapeutic range for Amitriptyline alone
-
Nortriptylineng/mLNo therapeutic range for Nortriptyline alone
-
Amitriptyline + Nortriptyline, Totalng/mLTherapeutic: 80 - 200
Toxic: > 300
Comment
(Effective 18-Oct-2022)
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| AMIT | Amitriptyline | 7566 | ng/mL |
| Nortriptyline | 7567 | ng/mL | |
| Combined Metabolite | 7568 | ng/mL |
Test Version
Last Updated
2022-10-14