Benzodiazepines; Clorazepate; Valium; Tranxene; Nordiazepam
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Diazepam LC-MS/MS, Serum
Test ID: DIAZSM S
Test
Aliases/Synonyms
Method
LC-MS/MS
Report Includes
Diazepam; Nordiazepam; Combined Metabolite
Specimens
Gel-separator tubes are not acceptable; Serum
Test Location
St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8
Test Version
13-Jan-2023
Specimen
Specimens
Gel-separator tubes are not acceptable; Serum
Collection Containers
Red top (no additive)
Sample Volume
1 mL
Specimen Comment
Avoid gel-separator tubes.
Collection & Handling
Handling Information
Separate and aliquot within 2 hours. Store and send cold or frozen.
Stability
| Ambient | 14 days |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |
Rejection Criteria
| Specimen | Gel tube |
|---|
Test Version
13-Jan-2023
Performance / Interpretation
Method
LC-MS/MS
Turnaround Time
12 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Diazepam | ng/mL |
|
nmol/L x 0.285 | |
| Nordiazepam | ng/mL |
|
nmol/L x 0.266 | |
| Combined Metabolite | ng/mL |
|
||
|
Therapeutic ranges based on Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
|
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Test Location
St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8
Test Version
13-Jan-2023
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| DIAZSM S | 64776Diazepam | ng/mL |
| 64777Nordiazepam | ng/mL | |
| 64778Combined Metabolite | ng/mL |
Test Version
13-Jan-2023