Test Overview
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
Chlordiazepoxide; Nordiazepam
Aliases/Synonyms
Librium
Specimen
Specimen Type
Gel-separator tubes are not acceptableSerum
Containers
Collection Containers
Red top (no additive)
Volume
Sample Volume
1 mL
Specimen Comment
Avoid gel-separator tubes.
Collection & Handling
Handling Information
Store and submit specimen protected from light in an amber vial.
Separate and aliquot within 2 hours. Store and send cold or frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 24 hours | 14 days | 14 days |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Gel tube or not protected from light |
Performance & Interpretation
Turnaround Time
12 days
Results
Name
Units
Reference Range
Conversion
-
Chlordiazepoxideng/mLTherapeutic: 400 - 3000
Toxic: > 3500nmol/L x 0.287 -
Nordiazepamng/mLTherapeutic: 100 - 500
Toxic: > 500nmol/L x 0.266
Comment
Therapeutic ranges based on Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: update 2017 and Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 6th ed pp. 1808.
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| CHDIAZSM S | Chlordiazepam | 64774 | ng/mL |
| Nordiazepam | 64775 | ng/mL |
Test Version
Last Updated
2023-01-13