G-6PD; G-6-PD; Glucose 6 phosphate dehydrogenase
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Glucose-6-phosphate dehydrogenase (G6PD), Whole Blood
Test ID: G6PD
Orderable by Ontario ND
Test
Aliases/Synonyms
Method
Kinetic Spectrophotometry
Platform
Alinity c
Report Includes
Glucose-6-Phosphate dehydrogenase
Specimens
Blood
Clinical Utility
G6PD activity is used for identifying G6PD deficiency that can be asymptomatic or underlie acute hemolytic anemias and chronic hemolysis. G6PD deficiency is an X-linked disorder caused by mutations in the G6PD gene. This condition can be asymptomatic, although patients can present with chronic hemolysis or episodic anemia following exposure to infections, fava beans or drugs (Higgins V. JALM 2021). However, transfusion of red blood cell products less than 3 months prior to testing, significantly elevated reticulocytes and significantly elevated leukocyte counts, can falsely elevate G6PD levels. In neonates where there is a strong clinical suspicion of G6PD deficiency, retesting in 3 months and/or referral to a paediatric haematologist for further evaluation may be warranted.
Test Location
University Health Network, 200 Elizabeth St, 11E-444, Toronto ON M5G 2C4
Test Version
13-Jan-2023
Specimen
Specimens
Blood
Collection Containers
Preferred
Yellow top (ACD)
Acceptable
Lavender top (EDTA)
Sample Volume
3 mL
Minimum Volume
1 mL
Collection & Handling
Handling Information
Do not freeze. Store and send cold.
Stability
| Refrigerated | 10 days |
|---|---|
| Frozen | Unacceptable |
Rejection Criteria
| Specimen | Frozen |
|---|
Test Version
13-Jan-2023
Performance / Interpretation
Method
Kinetic Spectrophotometry
Platform
Alinity c
Turnaround Time
7 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Glucose-6-Phosphate Dehydrogenase | U/g Hb |
|
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Transfusion of red blood cell products less than 3 months prior to testing, significantly elevated reticulocytes and significantly elevated leukocyte counts, can falsely elevate G6PDlevels. In neonates where there is a strong clinical suspicion of G6PD deficiency, retesting in 3 months and/or referral to a paediatric haematologist for further evaluation may be warranted |
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Test Location
University Health Network, 200 Elizabeth St, 11E-444, Toronto ON M5G 2C4
Test Version
13-Jan-2023
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| G6PD | 2960Glucose-6-P-dehydrogenase | U/g Hb |
Test Version
13-Jan-2023