Vanillylmandellic Acid (VMA) LC-MS/MS, 24hr Urine
Orderable by Ontario ND
Test Overview
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
VMA; VMA/Creat Ratio; Creatinine
Specimen
Specimen Type
Urine (24 hr)Containers
Collection Containers
Urine Container (24hr) 4L
Volume
Sample Volume
10 mL
Patient Preparation
The following foods and medications should be avoided for three (3) days prior to the collection of urine, and during the collection of the sample:
Foods containing high caffeine concentrations (e.g. coffee, tea, cocoa, chocolate, caffeinated beverages, foods containing high amine concentrations (e.g. bananas, avocados, cheese, walnuts, alcohol, fruit and juices) and foods containing vanilla can increase urinary HVA/VMA excretion. Essential hypertension, intense anxiety and intense physical exercise can also result in raised HVA/VMA excretion.
Medications and drugs such as Salicylate, Histamine, Acetaminophen, Levodopa, Ajmaline, Lithium, Epinephrine, Nitroglycerin, Glucagon, Rauwolfia Alkaloids and Guanethidine can increase HVA/VMA.
Contact your physician for approval before discontinuing any prescription medication. Be sure to discuss all non-prescription medications with your physician.
Collection & Handling
Collection Instructions
24-hour urine collected in a polyethylene container with 25 mL 6N Hydrochloric Acid. It is important that the urine is refrigerated during the collection. The pH of the urine must be between 2-4.
15 mL 6N HCl is recommended for children less than 5 years old.
Handling Information
The final pH must be maintained from 2 – 4.
Additional Information
Provide 24 hour volume and date of collection.
Stability
| Refrigerated | Frozen |
|---|---|
| 1 month | 90 days |
Performance & Interpretation
Turnaround Time
8 days
Results
-
VolumeL0.600 - 1.600
-
Creatinine/dmmol/d7.0 - 15.0
-
Vanillylmandelic Acid - Totalµmol/d< 2 y: ≤ 12.0
2 - < 5 y: ≤ 15.0
5 - < 10 y: ≤ 18.0
10 - < 20 y: ≤ 30.0
≥ 20 y: ≤ 35.0mg/24 hr x 5.05 -
VMA/Creat Ratioµmol/mmol cr< 2: ≤ 11.0
2 - 5 y: ≤ 6.5
5 - < 20 y: ≤ 5.0
≥ 20 y: ≤ 4.0
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| VMA | Volume | 7601 | L |
| Creatinine/L | 7637 | mmol/L | |
| Creatinine/d | 7602 | mmol/d | |
| VMA | 7603 | umol/d | |
| VMA/Creatinine Ratio, 24 Hour Urine | 7604 | umol/mmol creatinine |
Test Version
Last Updated
2022-11-16