Factor H Antibodies, Plasma

Anti-Factor H Antibodies; anti-CFH; Complement Factor H Ab

Factor H Antibodies

Plasma

Atypical hemolytic uremic syndrome (aHUS) is an inherited or acquired thrombotic microangiopathy (TMA) caused by dysregulated activation of the alternate pathway of the complement system.Factor H (FH) negatively regulates the alternate complement pathway.A loss of FH function by mutation or under the action of an inhibitor (auto-antibody) is associated with the onset of aHUS.The anti-FH antibody assay by ELISA confirms or invalidates a diagnosis of acquired aHUS due to the presence of anti-FH antibodies.