1-Methylhistamine;Histamine Metabolites;Urinary N-Methylhistamine;NMHR;NMH;N-Methylhistamine
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N-Methylhistamine, Random Urine
Test ID: NMHRU
Test
Aliases/Synonyms
Method
Various
Method Description
N-Methylhistamine: LC-MS/MS
Creatinine: Enzymatic Colorimetric Assay
Report Includes
N-Methylhistamine; Creatinine
Specimens
Urine
Random urine collections are preferred for patients with episodic symptoms, for example in the context of allergic reactions, brought on by specific environmental factors.
Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred; order N-Methylhistamine, 24 Hour Urine
Random urine collections are preferred for patients with episodic symptoms, for example in the context of allergic reactions, brought on by specific environmental factors.
Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred; order N-Methylhistamine, 24 Hour Urine
Test Location
Mayo Clinical Labs, Minnesota USA
Test Version
29-Sep-2022
Specimen
Specimens
Urine
Random urine collections are preferred for patients with episodic symptoms, for example in the context of allergic reactions, brought on by specific environmental factors.
Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred; order N-Methylhistamine, 24 Hour Urine
Random urine collections are preferred for patients with episodic symptoms, for example in the context of allergic reactions, brought on by specific environmental factors.
Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred; order N-Methylhistamine, 24 Hour Urine
Collection Containers
Mid-Stream Urine Container
Sample Volume
5 ml
Minimum Volume
3 ml
Patient Preparation
Patient must not be taking monoamine oxidase inhibitors (MAOI) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.
Collection & Handling
Collection Instructions
Collect a random urine specimen within a few hours of symptom onset. No Preservative.
Handling Information
Store and send cold or frozen.
Stability
| Ambient | 14 days |
|---|---|
| Refrigerated | 28 days |
| Frozen | 28 days |
Test Version
29-Sep-2022
Performance / Interpretation
Method
Various
Method Description
N-Methylhistamine: LC-MS/MS
Creatinine: Enzymatic Colorimetric Assay
Turnaround Time
11 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| N-methylhistamine | mcg/g creatinine |
|
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| Creatinine | mg/dL |
|
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Test Location
Mayo Clinical Labs, Minnesota USA
Test Version
29-Sep-2022
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| NMHR U | 63387N-Methylhistamine, Random, U | mcg/g Cr |
| 63388Creatinine, Random, U | mg/dL |
Test Version
29-Sep-2022