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Metanephrines – Fractionated LC-MS/MS, 24 hr Urine

Test ID: METF U

Test

Aliases/Synonyms

Fractionated metanephrines, Free Metanephrine, Metanephrines Free, urine, NMN, urine, Normetanephrine, free, Normetanephrines, urine

Method

LC-MS/MS

Report Includes

Free Normetanephrine; Free Metanephrine; Free Normetanephrine, 24hr; Free Normetanephrine/Creatinine Ratio; Free Metanephrine, 24hr; Free Metanephrine/Creatinine Ratio; 3-Methoxytyamine; 3-Methoxytyramine, 24hr; 3-Methoxytyramine/Creatinine Ratio; Volume; Creatinine/L; Creatinine/d

Specimens

Urine (24 hr)

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

21-Dec-2023

Specimen

Specimens

Urine (24 hr)

Sample Volume

25 mL

Patient Preparation

Restrict caffeine, nicotine and alcohol for 24 hours prior to collection. Discontinue Methyldopa (Aldomet) at least 5 days prior to collection. Avoid reserpine, alpha methyldopa, levodopa, monoamine oxidase inhibitors.

Collection & Handling

Collection Instructions

Collect urine in a container with 25 mL 6 mol/L (6N) HCl. It is important that the urine is refrigerated during the collection.

Handling Information

The final pH of the urine must be 2.0 – 4.0. State 24 hour collection volume and collection date.

Stability

Refrigerated 1 month
Frozen >1 month

Test Version

21-Dec-2023

Performance / Interpretation

Method

LC-MS/MS

Turnaround Time

10 days

Results

Name Units Reference Range Conversion Factor
Volume L
Creatinine nmol/L
Creatinine/d mmol/d
Free Normetanephrine nmol/L
Free Metanephrine nmol/L
Free Normetanephrine, 24hr nmol/d
  • Male: <300
  • Female: <300
Free Normetanephrine/Creatinine Ratio nmol/mmol creatinine
  • <34
Free Metanephrine, 24 hour nmol/d
  • Male: <270
  • Female: <170
Free Metanephrine/Creatinine Ratio nmol/mmol creatinine
  • <31
3-Methoxytyamine nmol/L
3-Methoxytyramine, 24hr nmol/d
  • Male: <380
  • Female: <300
3-Methoxytyramine/Creatinine Ratio nmol/mmol creatinine
  • <45

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

21-Dec-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
METF U 63310Normetanephrine Uncalculated Free nmol/L
63311Metanephrine Uncalculated Free nmol/L
6331224h Normetanephrine Free nmol/d
63313Normet/Crt Ratio nmol/mmol creat
6331424h Metanephrine Free nmol/d
63315Met/Crt Ratio nmol/mmol creat
633163-Methoxytyamine Uncalculated nmol/L
633173-Methoxytyramine, 24h nmol/d
633183-Methoxy/Creat Ratio nmol/mmol creat
7601Volume L
7637Creatinine/L mmol/L
7602Creatinine/d mmol/d

Test Version

21-Dec-2023