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Metanephrines – Fractionated LC-MS/MS, Random Urine

Test ID: METFRU

Test

Aliases/Synonyms

Fractionated Metanephrines, Metanephrines Free, urine, NMN, urine, Normetanephrine, free, Normetanephrines, urine

Method

LC-MS/MS

Report Includes

Free Normetanephrine; Free Normetanephrine/Creatinine Ratio; Free Metanephrine; Free Metanephrine/Creatinine Ratio; 3-Methoxytyramine; 3-Methoxytyramine/Creatinine Ratio; Creatinine

Specimens

Urine (Random)

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

21-Dec-2023

Specimen

Specimens

Urine (Random)

Sample Volume

25 mL

Patient Preparation

Restrict caffeine, nicotine and alcohol for 24 hours prior to collection. Discontinue Methyldopa (Aldomet) at least 5 days prior to collection. Avoid reserpine, alpha methyldopa, levodopa, monoamine oxidase inhibitors.

Collection & Handling

Handling Information

Acidify aliquot with 6 mol/L (6N) HCl. The final pH of the urine must be 2.0 – 4.0.

Stability

Refrigerated 1 month
Frozen >1 month

Test Version

21-Dec-2023

Performance / Interpretation

Method

LC-MS/MS

Turnaround Time

10 days

Results

Name Units Reference Range Conversion Factor
Creatinine nmol/L
Free Normetanephrine nmol/L
Free Normetanephrine/Creatinine Ratio nmol/mmol creatinine
Free Metanephrine nmol/L
Free Metanephrine/Creatinine Ratio nmol/mmol creatinine
  • <31
3-Methoxytyramine nmol/L
3-Methoxytyramine/Creatinine Ratio nmol/mmol creatinine
  • <45.0

Test Location

St. Michael's Hospital, 30 Bond Street, Toronto ON M5B 1W8

Test Version

21-Dec-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
METFRU 63304Normetanephrine Random Free nmol/L
63305Normet/Crt Ratio nmol/mmol creat
63306Metanephrine Random Free nmol/L
63307Met/Crt Ratio nmol/mmol creat
63308Methoxytyramine Random nmol/L
633093-Methoxytyramine/Creat Ratio nmol/mmol creat
28004Creatinine Rand Urine mmol/L

Test Version

21-Dec-2023