Anti GM1 IgG, Anti GM2 IgG, Anti GM3 IgG, Anti GD1a IgG, Anti GD1b IgG, Anti GT1b IgG, Anti GQ1b IgG, Anti GM1 IgM, Anti GM2 IgM, Anti GM3 IgM, Anti GD1a IgM, Anti GD1b
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Gangliosides Antibodies Profile IgG and IgM, Serum
Test ID: GANGM S
Test
Aliases/Synonyms
Method
Immunoblot
Platform
EUROImmun EUROBlotOne
Report Includes
Anti GM1 IgG; Anti GM2 IgG; Anti GM3 IgG; Anti GD1a IgG; Anti GD1b IgG; Anti GT1b IgG; Anti GQ1b IgG; Anti GM1 IgM; Anti GM2 IgM; Anti GM3 IgM; Anti GD1a IgM; Anti GD1b IgM; Anti GT1b IgM; Anti GQ1b IgM
Specimens
Serum; Plasma
Clinical Utility
TABLE 1: Anti-Gangliosides Associations:
| Antibodies Against | Ig Class | Associated Neuropathies |
|---|---|---|
| GM1, GD1a, GD1b and GT1b | IgM | Multifocal motor neuropathy (MMN) |
| GM2 and GM3 | IgM, IgG | Multifocal motor neuropathy (MMN) |
| GM3, GD1a and GT1b | IgM | Guillain-Barré syndrome (GBS) |
| GM1, GM2, GD1b, GQ1b | IgM, IgG | Guillain-Barré syndrome (GBS) |
| GM2, GD1a and GD1b | IgM | Chronic inflammatory demyelinating polyneuropathy (CIDP) |
| GM3 | IgM, IgG | Chronic inflammatory demyelinating polyneuropathy (CIDP) |
| GQ1b | IgG | Miller-Fisher syndrome (MFS) |
| GD1b | IgG | Sensory neuropathy |
Test Location
London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5
Test Version
25-Jul-2024
Specimen
Specimens
Serum; Plasma
Collection Containers
Preferred
Serum (Red Top)
Acceptable
["Plasma (EDTA, Heparin or Citrate)"]
Sample Volume
1.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Store and send frozen.
Stability
| Refrigerated | 14 days |
|---|---|
| Frozen | 30 days |
Test Version
25-Jul-2024
Performance / Interpretation
Method
Immunoblot
Platform
EUROImmun EUROBlotOne
Turnaround Time
22 days
Results
| Name | Units | Reference Range | Conversion Factor | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anti GM1 IgG |
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Immunoblot results will be reported as either negative or positive for specific antibodies:
(+) Borderline 1+ Weak Positive 2+ Positive 3+ Strong Positive TABLE 1: Anti-Gangliosides Associations:
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| Anti GM2 IgG |
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| Anti GM3 IgG |
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| Anti GD1a IgG |
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| Anti GD1b IgG |
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| Anti GT1b IgG |
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| Anti GQ1b IgG |
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| Anti GM1 IgM |
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| Anti GM2 IgM |
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| Anti GM3 IgM |
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| Anti GD1a IgM |
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| Anti GD1b IgM |
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| Anti GT1b IgM |
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| Anti GQ1b IgM |
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Test Location
London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5
Test Version
25-Jul-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| GANGM S | 63208Anti GM1 IgG | |
| 63209Anti GM2 IgG | ||
| 63210Anti GM3 IgG | ||
| 63211Anti GD1a IgG | ||
| 63212Anti GD1b IgG | ||
| 63213Anti GT1b IgG | ||
| 63214Anti GQ1b IgG | ||
| 63215Anti GM1 IgM | ||
| 63216Anti GM2 IgM | ||
| 63217Anti GM3 IgM | ||
| 63218Anti GD1a IgM | ||
| 63219Anti GD1b IgM | ||
| 63220Anti GT1b IgM | ||
| 63221Anti GQ1b IgM |
Test Version
25-Jul-2024