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Gangliosides Antibodies Profile IgG and IgM, Serum

Test ID: GANGM S

Test

Aliases/Synonyms

Anti GM1 IgG, Anti GM2 IgG, Anti GM3 IgG, Anti GD1a IgG, Anti GD1b IgG, Anti GT1b IgG, Anti GQ1b IgG, Anti GM1 IgM, Anti GM2 IgM, Anti GM3 IgM, Anti GD1a IgM, Anti GD1b

Method

Immunoblot

Platform

EUROImmun EUROBlotOne

Report Includes

Anti GM1 IgG; Anti GM2 IgG; Anti GM3 IgG; Anti GD1a IgG; Anti GD1b IgG; Anti GT1b IgG; Anti GQ1b IgG; Anti GM1 IgM; Anti GM2 IgM; Anti GM3 IgM; Anti GD1a IgM; Anti GD1b IgM; Anti GT1b IgM; Anti GQ1b IgM

Specimens

Serum; Plasma

Clinical Utility

TABLE 1: Anti-Gangliosides Associations:

Antibodies Against Ig Class Associated Neuropathies
GM1, GD1a, GD1b and GT1b IgM Multifocal motor neuropathy (MMN)
GM2 and GM3 IgM, IgG Multifocal motor neuropathy (MMN)
GM3, GD1a and GT1b IgM Guillain-Barré syndrome (GBS)
GM1, GM2, GD1b, GQ1b IgM, IgG Guillain-Barré syndrome (GBS)
GM2, GD1a and GD1b IgM Chronic inflammatory demyelinating polyneuropathy (CIDP)
GM3 IgM, IgG Chronic inflammatory demyelinating polyneuropathy (CIDP)
GQ1b IgG Miller-Fisher syndrome (MFS)
GD1b IgG Sensory neuropathy

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

5-Feb-2020

Specimen

Specimens

Serum; Plasma

Collection Containers

Preferred

Serum (Red Top)

Acceptable

Plasma (EDTA, Heparin or Citrate)

Sample Volume

1.0 mL

Minimum Volume

0.5 mL

Collection & Handling

Handling Information

Store and send frozen.

Stability

Refrigerated 14 days

Test Version

5-Feb-2020

Performance / Interpretation

Method

Immunoblot

Platform

EUROImmun EUROBlotOne

Turnaround Time

22 days

Results

Name Units Reference Range Conversion Factor
Anti GM1 IgG
  • Negative
Immunoblot results will be reported as either negative or positive for specific antibodies:
(+) Borderline
1+ Weak Positive
2+ Positive
3+ Strong Positive

TABLE 1: Anti-Gangliosides Associations:

Antibodies AgainstIg ClassAssociated Neuropathies
GM1, GD1a, GD1b and GT1bIgMMultifocal motor neuropathy (MMN)
GM2 and GM3IgM, IgGMultifocal motor neuropathy (MMN)
GM3, GD1a and GT1bIgMGuillain-Barré syndrome (GBS)
GM1, GM2, GD1b, GQ1bIgM, IgGGuillain-Barré syndrome (GBS)
GM2, GD1a and GD1bIgMChronic inflammatory demyelinating polyneuropathy (CIDP)
GM3IgM, IgGChronic inflammatory demyelinating polyneuropathy (CIDP)
GQ1bIgGMiller-Fisher syndrome (MFS)
GD1bIgGSensory neuropathy
Anti GM2 IgG
  • Negative
Anti GM3 IgG
  • Negative
Anti GD1a IgG
  • Negative
Anti GD1b IgG
  • Negative
Anti GT1b IgG
  • Negative
Anti GQ1b IgG
  • Negative
Anti GM1 IgM
  • Negative
Anti GM2 IgM
  • Negative
Anti GM3 IgM
  • Negative
Anti GD1a IgM
  • Negative
Anti GD1b IgM
  • Negative
Anti GT1b IgM
  • Negative
Anti GQ1b IgM
  • Negative

Test Location

London Health Sciences Centre, 339 Windermere Road, London ON N6A 5A5

Test Version

5-Feb-2020

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
GANGM S 63208Anti GM1 IgG
63209Anti GM2 IgG
63210Anti GM3 IgG
63211Anti GD1a IgG
63212Anti GD1b IgG
63213Anti GT1b IgG
63214Anti GQ1b IgG
63215Anti GM1 IgM
63216Anti GM2 IgM
63217Anti GM3 IgM
63218Anti GD1a IgM
63219Anti GD1b IgM
63220Anti GT1b IgM
63221Anti GQ1b IgM

Test Version

5-Feb-2020