CRMP-5-IgG Western Blot
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Collapsin Response-Mediator Protein-5-IgG (CRMP-5-IgG) Western Blot, CSF
Test ID: CRMP CSF
Test
Method
Western Blot
Method Description
Western blot is performed on denatured full-length recombinant humancollapsin response-mediator protein-5 (CRMP-5), reduced and subjected to electrophoresis on 10% polyacrylamide gel. IgG is detected autoradiographically by enhanced chemiluminescence.(Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49[2]:146-154)
Report Includes
Specimens
CSF
Clinical Utility
This testing is recommended in cases of chorea, vision loss, cranial neuropathy and myelopathy.
Clinical Information at external website.
Test Location
Mayo Clinical Labs, Minnesota USA
Test Version
9-Dec-2019
Specimen
Specimens
CSF
Sample Volume
3 mL
Minimum Volume
2 mL
Collection & Handling
Handling Information
Store and send frozen
Stability
| Ambient | 72 hours |
|---|---|
| Refrigerated | 28 days |
| Frozen | 28 days |
Rejection Criteria
| Hemolysis | Gross |
|---|---|
| Lipemia | Gross |
| Other | Grossly icteric |
Test Version
9-Dec-2019
Performance / Interpretation
Method
Western Blot
Method Description
Western blot is performed on denatured full-length recombinant humancollapsin response-mediator protein-5 (CRMP-5), reduced and subjected to electrophoresis on 10% polyacrylamide gel. IgG is detected autoradiographically by enhanced chemiluminescence.(Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49[2]:146-154)
Turnaround Time
10 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| CRMP-5-IgG Western Blot | None |
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References:
Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49(2):146?154. Cross SA, Salomao DR, Parisi JE, et al: Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol 2003;54:38?50 |
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Test Location
Mayo Clinical Labs, Minnesota USA
Test Version
9-Dec-2019
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| CRMP CSF | 63136CRMP-5-IgG Western Blot, CSF | None |
Test Version
9-Dec-2019