Test Overview
Method
Competitive binding enzyme immunoassay
Analytical Platform
Roche Cobas 6000
Result Included
Tobramycin - Peak
Aliases/Synonyms
Aminoglycoside
Specimen
Specimen Type
SerumContainers
Preferred Containers
Red top (no additive)
Acceptable Containers
Gold top (clot activator & gel)
Volume
Sample Volume
1 mL
Collection & Handling
Collection Instructions
For traditional dosing, collect sample 30 minutes after end of dose infusion. Wait until the third dose before collecting samples for therapeutic monitoring.
For extended dosing, after the third dose collect a sample 8 – 12 hours after end of dose infusion. Record the exact time of sampling and use nomogram for dosage adjustment if necessary.
Handling Information
Store and send frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 4 hours | 7 days | 30 days |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Hemolysis | Grossly |
| Icterus | Present |
Performance & Interpretation
Turnaround Time
2 days
Results
Name
Units
Reference Range
Conversion
-
Tobramycin - Peakmg/LFor traditional (conventional) dosing method:
Pre-dose: <2.0 mg/L for adults and pediatrics
Half-hour post-dose: 4.0 - 10.0 mg/L for adults ; 5.0 - 10.0 mg/L for pediatrics
For extended interval (once daily) dosing method:
Pre-dose <1.0 mg/L for adults
8 - 12 hours post-dose for adults and use nomogram for interpretation;
3 and 6 hours post-dose for pediatrics and use nomogram for interpretation.
Comment
Refer to guidelines for Aminoglycoside dosing at your institution.
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| TOBRAP | Tobramycin Post | 2562 | mg/L |
Test Version
Last Updated
2023-08-23