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Thiopurine Methyltransferase (TPMT), Blood

Test ID: TPMT

Test

Method

Enzymatic - UPLC/Fluorescence

Report Includes

Thiopurine Methyltransferase (TPMT) Activity

Specimens

Whole Blood (EDTA)

Test Location

Health Sciences Centre Laboratory, 820 Sherbrook Street, Winnipeg MB R3A 1R9

Test Version

12-May-2023

Specimen

Specimens

Whole Blood (EDTA)

Sample Volume

4 mL

Patient Preparation

Patients should be tested prior toAzathioprine or 6-MP treatment.

Collection & Handling

Collection Instructions

Avoid gel-separator tubes. Adult minimum 1.0 mL. Pediatric: 1.0 mL whole blood,0.5 mL minimum.Falsely low TPMT activity is observed in patients being treatedwith aminosalicylates. Red blood cell transfusion pre-test may produce falseindication of patient's TPMT status. Specimenmust be received at ICL Mon-Thu within 4 days of collection. State collectiondate. TPMT Genotyping is also available - see separate listing.

Handling Information

Do not freeze - store and send cold.

Stability

Refrigerated 7 days
Frozen Unacceptable

Test Version

12-May-2023

Performance / Interpretation

Method

Enzymatic - UPLC/Fluorescence

Turnaround Time

5 days

Results

Name Units Reference Range Conversion Factor
Thiopurine Methyltransferase (TPMT) Activity nmol/g Hb/h
  • Low Activity: <10
  • Intermediate 10 - 40
  • Normal Activity: >40

Test Location

Health Sciences Centre Laboratory, 820 Sherbrook Street, Winnipeg MB R3A 1R9

Test Version

12-May-2023

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
TPMT 39162TPMT nmol/g Hb/h

Test Version

12-May-2023