Thiopurine Methyltransferase (TPMT) Activity
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Thiopurine Methyltransferase (TPMT), Blood
Test ID: TPMT
Test
Method
Enzymatic - UPLC/Fluorescence
Report Includes
Specimens
Whole Blood (EDTA)
Test Location
Health Sciences Centre Laboratory, 820 Sherbrook Street, Winnipeg MB R3A 1R9
Test Version
12-May-2023
Specimen
Specimens
Whole Blood (EDTA)
Sample Volume
4 mL
Patient Preparation
Patients should be tested prior toAzathioprine or 6-MP treatment.
Collection & Handling
Collection Instructions
Avoid gel-separator tubes. Adult minimum 1.0 mL. Pediatric: 1.0 mL whole blood,0.5 mL minimum.Falsely low TPMT activity is observed in patients being treatedwith aminosalicylates. Red blood cell transfusion pre-test may produce falseindication of patient's TPMT status. Specimenmust be received at ICL Mon-Thu within 4 days of collection. State collectiondate. TPMT Genotyping is also available - see separate listing.
Handling Information
Do not freeze - store and send cold.
Stability
| Refrigerated | 7 days |
|---|---|
| Frozen | Unacceptable |
Test Version
12-May-2023
Performance / Interpretation
Method
Enzymatic - UPLC/Fluorescence
Turnaround Time
5 days
Results
| Name | Units | Reference Range | Conversion Factor |
|---|---|---|---|
| Thiopurine Methyltransferase (TPMT) Activity | nmol/g Hb/h |
|
Test Location
Health Sciences Centre Laboratory, 820 Sherbrook Street, Winnipeg MB R3A 1R9
Test Version
12-May-2023
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| TPMT | 39162TPMT | nmol/g Hb/h |
Test Version
12-May-2023