Anti-MOG; MOG Antibodies
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Myelin-Oligodendrocyte Glycoprotein (MOG) Antibodies, Serum
Test ID: MOG S
Test
Aliases/Synonyms
Method
Cell-Based Indirect Immunofluorescence
Method Description
Indirect immunofluorescence using MOG-transfected HEK cells (fixed cell-based assay).
Report Includes
Myelin-Oligodendrocyte Glycoprotein Antibodies (Anti-MOG)
Specimens
Serum
Clinical Utility
Many cases of Neuromyelitis Optica-spectrum disorders (NMOSD) are misdiagnosed as Multiple Sclerosis. As correct diagnosis is critical for prognosis, optimal treatment and prediction of relapse, initial testing for both Aquaporin 4 (AQP4) Antibodies and Myelin-Oligodendrocyte Glycoprotein (MOG) Antibodies is strongly recommended for new cases of NMOSD – see separate test listings. AQP4 antibodies are detected in about 80% of patients with NMO. Of these seronegative AQP-4 cases 7% will harbor MOG antibodies. Patients very rarely harbour both antibodies.
Test Location
St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5
Test Version
29-Aug-2024
Specimen
Specimens
Serum
Collection Containers
Preferred
Red Top (no additive)
Acceptable
Gold Top (SST)
Sample Volume
1 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Separate as soon as possible. Store and send frozen.
Additional Information
Avoid repeat freeze/thaw cycles.
Stability
| Ambient | 6 hours |
|---|---|
| Refrigerated | 14 days |
| Frozen | 30 days |
Additional Stability Information
Avoid repeat freeze/thaw cycles.
Rejection Criteria
| Hemolysis | Gross |
|---|---|
| Lipemic | Gross |
Test Version
29-Aug-2024
Performance / Interpretation
Method
Cell-Based Indirect Immunofluorescence
Method Description
Indirect immunofluorescence using MOG-transfected HEK cells (fixed cell-based assay).
Turnaround Time
9 days
Results
| Name | Units | Reference Range | Conversion Factor | |
|---|---|---|---|---|
| Myelin-Oligodendrocyte Glycoprotein Antibodies (Anti-MOG) |
|
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|
Low Positive (1:10): Positive at 1:10 dilution and Negative at 1:100 dilution, indicating an endpoint titre that is between 1:10 and 1:100.
Clear Positive (1:100): Positive at 1:10 dilution and Positive at 1:100 dilution, indicating an endpoint titre that is greater than or equal to 1:100. |
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Test Location
St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5
Test Version
29-Aug-2024
Interface / Setup
HL7 Interface Codes
| Order Code | Result Codes | Units |
|---|---|---|
| MOG S | 62783Anti MOG |
Test Version
29-Aug-2024