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Myelin-Oligodendrocyte Glycoprotein (MOG) Antibodies, Serum

Test ID: MOG S

Test

Aliases/Synonyms

Anti-MOG; MOG Antibodies

Method

Cell-Based Indirect Immunofluorescence

Method Description

Indirect immunofluorescence using MOG-transfected HEK cells (fixed cell-based assay).

Report Includes

Myelin-Oligodendrocyte Glycoprotein Antibodies (Anti-MOG)

Specimens

Serum

Clinical Utility

Many cases of Neuromyelitis Optica-spectrum disorders (NMOSD) are misdiagnosed as Multiple Sclerosis. As correct diagnosis is critical for prognosis, optimal treatment and prediction of relapse, initial testing for both Aquaporin 4 (AQP4) Antibodies and Myelin-Oligodendrocyte Glycoprotein (MOG) Antibodies is strongly recommended for new cases of NMOSD – see separate test listings. AQP4 antibodies are detected in about 80% of patients with NMO. Of these seronegative AQP-4 cases 7% will harbor MOG antibodies. Patients very rarely harbour both antibodies.

Test Location

St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5

Test Version

29-Aug-2024

Specimen

Specimens

Serum

Collection Containers

Preferred

Red Top (no additive)

Acceptable

Gold Top (SST)

Sample Volume

1 mL

Minimum Volume

0.5 mL

Collection & Handling

Handling Information

Separate as soon as possible. Store and send frozen.

Additional Information

Avoid repeat freeze/thaw cycles.

Stability

Ambient 6 hours
Refrigerated 14 days
Frozen 30 days

Additional Stability Information

Avoid repeat freeze/thaw cycles.

Rejection Criteria

Hemolysis Gross
Lipemic Gross

Test Version

29-Aug-2024

Performance / Interpretation

Method

Cell-Based Indirect Immunofluorescence

Method Description

Indirect immunofluorescence using MOG-transfected HEK cells (fixed cell-based assay).

Turnaround Time

9 days

Results

Name Units Reference Range Conversion Factor
Myelin-Oligodendrocyte Glycoprotein Antibodies (Anti-MOG)
  • Negative
Low Positive (1:10): Positive at 1:10 dilution and Negative at 1:100 dilution, indicating an endpoint titre that is between 1:10 and 1:100.
Clear Positive (1:100): Positive at 1:10 dilution and Positive at 1:100 dilution, indicating an endpoint titre that is greater than or equal to 1:100.

Test Location

St. Joseph's Hospital, 30 The Queensway, Toronto ON M6R 1B5

Test Version

29-Aug-2024

Interface / Setup

HL7 Interface Codes

Order Code Result Codes Units
MOG S 62783Anti MOG

Test Version

29-Aug-2024