Test Overview
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
Itraconazole; Hydroxyitraconazole
Specimen
Specimen Type
Avoid gel separator tubesSerum
Plasma
Containers
Preferred Containers
Green top (sodium heparin)
Acceptable Containers
Red top (no additive)
Volume
Sample Volume
1.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Collection Instructions
Collect immediately before next scheduled dose or at least 12 hours after last dose.
Handling Information
Store and send frozen.
Stability
| Refrigerated | Frozen |
|---|---|
| 1 day | > 1 day |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Collected in gel-separator tube |
Performance & Interpretation
Turnaround Time
10 days
Results
Name
Units
Reference Range
Conversion
-
Itraconazoleµg/mLTherapeutic: > 0.5
Toxic: > 5.0 -
Hydroxyitraconazoleµg/mLNone
Comment
No therapeutic range has been established for hydroxyitraconazole; activity and serum concentrations are similar to parent drug. Some studies suggest hydroxyitraconazole levels are slightly higher than itraconazole levels, with a HO-itraconazole:itraconazole ratio 1.1 - 2.5. Other studies suggest the combined itraconazole and HO-itraconazole concentration should be >1.5 ug/mL.
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| ITRAEOR SP | Itraconazole | 65007 | ug/mL |
| Hydroxyitraconazole | 65751 | ug/mL |
Test Version
Last Updated
2024-11-15